The hope for an HIV vaccine based on induction of CD8+ T lymphocytes--a review.

Memórias do Instituto Oswaldo Cruz
David I Watkins

Abstract

The only long-term and cost-effective solution to the human immunodeficiency virus (HIV) epidemic in the developing world is a vaccine that prevents individuals from becoming infected or, once infected, from passing the virus on to others. There is currently little hope for an AIDS vaccine. Conventional attempts to induce protective antibody and CD8(+) lymphocyte responses against HIV and simian immunodeficiency virus (SIV) have failed. The enormous diversity of the virus has only recently been appreciated by vaccinologists, and our assays to determine CD8(+) lymphocyte antiviral efficacy are inadequate. The central hypothesis of a CTL-based vaccine is that particularly effective CD8(+) lymphocytes directed against at least five epitopes that are derived from regions under functional and structural constraints will control replication of pathogenic SIV. This would be somewhat analogous to control of virus replication by triple drug therapy or neutralizing antibodies.

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Citations

Apr 16, 2009·Clinical Microbiology Reviews·Jenefer M BlackwellDavid Burgner
Feb 19, 2010·Journal of Virology·Mauricio A MartinsDavid I Watkins
Oct 31, 2013·AIDS Research and Human Retroviruses·Stuart Z Shapiro
Oct 9, 2009·International Reviews of Immunology·Antonella CaputoBarbara Ensoli
Feb 13, 2016·EBioMedicine·Karen A O MartinsSina Bavari
Oct 23, 2012·Cell Host & Microbe·Dennis R BurtonRichard Wyatt
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Mauricio M RodriguesJosé Ronnie Vasconcelos
Feb 23, 2018·Frontiers in Immunology·Daniela TeixeiraIeda Maria Longo-Maugéri
Feb 23, 2017·Frontiers in Immunology·Juliana de Souza ApostólicoDaniela Santoro Rosa
Mar 7, 2019·Microorganisms·Yiding Yang, Vitaly V Ganusov

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