PMID: 6411985Jul 1, 1983Paper

The hormonal and cellular control of Sertoli cell secretion

Journal of Steroid Biochemistry
J P MatherC W Bardin

Abstract

Sertoli cells synthesize and secrete a number of cell-specific products including androgen binding protein (ABP), as well as "serum proteins" such as transferrin. The secretion of these proteins is regulated by extra-testicular hormones such as FSH and insulin; Leydig cell-produced steroids and proopiomelano-cortin-derived peptides; and the presence of peritubular myoid cells and/or factors secreted by these cells. Many of the Sertoli cell proteins are secreted in a cyclic fashion during the different stages of the spermatogenic cycle suggesting communication between Sertoli cells and developing germ cells. The availability of quantitative measurements for Sertoli cell-specific proteins such as ABP make it feasible to follow Sertoli cell function in vivo by measuring these products in serum. A bidirectional secretion of proteins by Sertoli cells is proposed to explain the presence of specific peptides in the male reproductive tract and blood.

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Citations

Jul 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A JaneckiA Steinberger
Feb 1, 1985·Journal of Steroid Biochemistry·M H PerrardA Dazord
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