The hormonal pathway controlling cell death during metamorphosis in a hemimetabolous insect

Developmental Biology
Daniel Mané-PadrósDavid Martín

Abstract

Metamorphosis in holometabolous insects is mainly based on the destruction of larval tissues. Intensive research in Drosophila melanogaster, a model of holometabolan metamorphosis, has shown that the steroid hormone 20-hydroxyecdysone (20E) signals cell death of larval tissues during metamorphosis. However, D. melanogaster shows a highly derived type of development and the mechanisms regulating apoptosis may not be representative in the insect class context. Unfortunately, no functional studies have been carried out to address whether the mechanisms controlling cell death are present in more basal hemimetabolous species. To address this, we have analyzed the apoptosis of the prothoracic gland of the cockroach Blattella germanica, which undergoes stage-specific degeneration just after the imaginal molt. Here, we first show that B. germanica has two inhibitor of apoptosis (IAP) proteins and that one of them, BgIAP1, is continuously required to ensure tissue viability, including that of the prothoracic gland, during nymphal development. Moreover, we demonstrate that the degeneration of the prothoracic gland is controlled by a complex 20E-triggered hierarchy of nuclear receptors converging in the strong activation of the death-indu...Continue Reading

References

Oct 16, 1999·Nature·J W Truman, L M Riddiford
Dec 28, 1999·Molecular and Cellular Endocrinology·K MiuraA S Raikhel
Sep 13, 2000·Molecular Cell·C Y LeeE H Baehrecke
Nov 6, 2003·Insect Biochemistry and Molecular Biology·J CruzX Bellés
Dec 12, 2003·Development·Damali N Martin, Eric H Baehrecke
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Viravuth P Yin, Carl S Thummel
Mar 31, 2005·Seminars in Cell & Developmental Biology·Viravuth P Yin, Carl S Thummel
Jan 24, 2006·Journal of Insect Physiology·David MartínXavier Bellés
Nov 17, 2006·Mechanisms of Development·R Parthasarathy, Subba R Palli
Jun 27, 2007·The Journal of Cell Biology·Viravuth P YinArash Bashirullah
Mar 22, 2008·Journal of Insect Physiology·Lynn M Riddiford
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Josefa CruzXavier Bellés
Jun 6, 2009·Apoptosis : an International Journal on Programmed Cell Death·Mariam Orme, Pascal Meier

❮ Previous
Next ❯

Citations

Apr 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Enric UreñaDavid Martín
Nov 6, 2015·Molecular Biology and Evolution·Enric UreñaDavid Martín
Feb 26, 2013·Journal of Insect Physiology·Asano IshikawaToru Miura
Nov 28, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Orathai Kamsoi, Xavier Belles
Aug 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gianluca Tettamanti, Morena Casartelli
Aug 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Xavier Belles
Oct 21, 2020·Development·Orathai Kamsoi, Xavier Belles
Jan 29, 2021·Microbiology and Molecular Biology Reviews : MMBR·Daniel PinosPatricia Hernández-Martínez
Oct 17, 2020·Current Opinion in Insect Science·Gyunghee Lee, Jae H Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis