The hormone melatonin stimulates renoprotective effects of "early outgrowth" endothelial progenitor cells in acute ischemic kidney injury

American Journal of Physiology. Renal Physiology
Daniel PatschanG A Müller

Abstract

Endothelial progenitor cells (EPCs) protect the kidney from acute ischemic injury. The aim of this study was to analyze whether pretreatment of murine "early outgrowth" EPCs (eEPCs) with the hormone melatonin increases the cells' renoprotective effects in the setting of murine acute ischemic renal failure. Male (8-12 wk old) C57Bl/6N mice were subjected to unilateral ischemia-reperfusion injury postuninephrectomy (40 min). Postischemic animals were injected with either 0.5×10(6) untreated syngeneic murine eEPCs or with cells, pretreated with melatonin for 1 h. Injections were performed shortly after reperfusion of the kidney. While animals injected with untreated cells developed acute renal failure, eEPC pretreatment with melatonin dramatically improved renoprotective actions of the cells. These effects were completely reversed after cell pretreatment with melatonin and the MT-1/-2 antagonist luzindole. In vitro analysis revealed that melatonin reduced the amount of tumor growth factor-β-induced eEPC apoptosis/necrosis. Secretion of vascular endothelial growth factor by the cells was markedly stimulated by the hormone. In addition, migratory activity of eEPCs was enhanced by melatonin and supernatant from melatonin-treated eEPC...Continue Reading

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Citations

Sep 21, 2012·American Journal of Physiology. Renal Physiology·Qingqing Wei, Zheng Dong
Jan 17, 2014·Journal of Nephrology·Daniel PatschanGerhard Anton Müller
Aug 21, 2015·Journal of Nephrology·Daniel PatschanGerhard Anton Müller
May 20, 2016·American Journal of Physiology. Renal Physiology·D PatschanG A Müller
Jun 14, 2018·American Journal of Physiology. Renal Physiology·K SchwarzeD Patschan
Aug 1, 2014·American Journal of Physiology. Renal Physiology·D PatschanG A Müller
Jan 23, 2016·American Journal of Physiology. Renal Physiology·D PatschanG A Müller
May 17, 2013·American Journal of Physiology. Renal Physiology·Daniel PatschanGerhard A Müller
Apr 11, 2014·International Journal of Molecular Medicine·Gang DuZicheng Li
Feb 4, 2021·Journal of Inflammation·Afshin RahbarghaziHadi Rajabi
Jun 3, 2021·International Journal of Molecular Sciences·Karla Johanna Ruth Hoyer-AlloRoman-Ulrich Müller

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