The hormone-sensitive lipase C-60G promoter polymorphism is associated with increased waist circumference in normal-weight subjects

International Journal of Obesity : Journal of the International Association for the Study of Obesity
E CarlssonM Ridderstråle

Abstract

Hormone-sensitive lipase (HSL) is a key enzyme in the mobilization of fatty acids from triglyceride stores in adipocytes. The aim of the present study was to investigate the role of the HSL gene promoter variant C-60G, a polymorphism which previously has been associated with reduced promoter activity in vitro, in obesity and type 2 diabetes. We genotyped two materials consisting of obese subjects and non-obese controls, one material with offspring-parents trios, where the offspring was abdominally obese and one material with trios, where the offspring had type 2 diabetes or impaired glucose homeostasis. HSL promoter containing the HSL C-60G G-allele was generated and tested against a construct with the C-allele in HeLa cells and primary rat adipocytes. HSL mRNA levels were quantified in subcutaneous and visceral fat from 33 obese subjects. We found that the common C-allele was associated with increased waist circumference and WHR in lean controls, but there was no difference in genotype frequency between obese and non-obese subjects. There was a significant increased transmission of C-alleles to the abdominally obese offspring but no increased transmission of C-alleles was observed to offspring with impaired glucose homeostasis...Continue Reading

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Citations

Jun 2, 2011·Chemical Reviews·Rosalind A Coleman, Douglas G Mashek
Jul 22, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F-Y GongY-F Shi
Sep 17, 2011·Systems Biology in Reproductive Medicine·Akram VatannejadHeidar Tavilani
Dec 25, 2010·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Feng-Ying GongHong-Bo Yang
Jun 15, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I Dahlman, P Arner
Sep 18, 2020·Tropical Animal Health and Production·Tahreer M Al-ThuwainiZainab A Mahdi

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