The Host Autophagy During Toxoplasma Infection

Frontiers in Microbiology
Minmin WuJian Du

Abstract

Autophagy is an important homeostatic mechanism, in which lysosomes degrade and recycle cytosolic components. As a key defense mechanism against infections, autophagy is involved in the capture and elimination of intracellular parasites. However, intracellular parasites, such as Toxoplasma gondii, have developed several evasion mechanisms to manipulate the host cell autophagy for their growth and establish a chronic infection. This review provides an insight into the autophagy mechanism used by the host cells in the control of T. gondii and the host exploitation by the parasite. First, we summarize the mechanism of autophagy, xenophagy, and LC3-associated phagocytosis. Then, we illustrate the process of autophagy proteins-mediated T. gondii clearance. Furthermore, we discuss how the parasite blocks and exploits this process for its survival.

References

Dec 1, 1995·The Journal of Infectious Diseases·D K Howe, L D Sibley
Aug 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J G Montoya, J S Remington
Mar 27, 2001·Nature Reviews. Molecular Cell Biology·Y Ohsumi
May 2, 2002·Trends in Parasitology·Russell E LyonsCraig W Roberts
Jun 15, 2004·Lancet·J G Montoya, O Liesenfeld
Jan 17, 2007·Autophagy·Carlos S SubausteMatthew Wessendarp
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos S SubausteMatthew Wessendarp
Jan 15, 2008·Cell·Beth Levine, Guido Kroemer
Nov 11, 2008·Cell Host & Microbe·Ryan J Whitmarsh, Christopher A Hunter
Nov 26, 2008·The Journal of Biological Chemistry·Yubao WangAmos Orlofsky
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanlin ZhaoGeorge S Yap
May 12, 2009·Memórias do Instituto Oswaldo Cruz·Carlos S Subauste
Jun 6, 2009·Nature Reviews. Molecular Cell Biology·Hitoshi NakatogawaYoshinori Ohsumi
Jan 30, 2010·Cellular Microbiology·Aliaksandr KhaminetsJonathan C Howard
May 21, 2010·The Journal of Parasitology·Peng ZhouJun-Long Zhao
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michael L ReeseJon P Boyle
May 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michael S BehnkeL David Sibley
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Noboru MizushimaYoshinori Ohsumi
Jul 18, 2012·PLoS Biology·Martin C FleckensteinTobias Steinfeldt
Mar 20, 2013·Infection and Immunity·Jennifer Van GrolCarlos S Subauste
May 10, 2013·The New England Journal of Medicine·Andrea DoriaLeonardo Punzi
May 21, 2013·Nature Cell Biology·Ryan C RussellKun-Liang Guan
Jun 4, 2013·Antioxidants & Redox Signaling·Katherine R Parzych, Daniel J Klionsky
Jul 9, 2013·Handbook of Clinical Neurology·Sandra K Halonen, Louis M Weiss
Jan 5, 2014·Nature Reviews. Microbiology·Ju Huang, John H Brumell
Feb 15, 2014·Disease Models & Mechanisms·Alexandru ParlogIldiko Rita Dunay
Feb 25, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jun OhshimaMasahiro Yamamoto

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Methods Mentioned

BETA
lipidation
GTPases
GTPase
ubiquitination

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