The host cellular immune response to cytomegalovirus targets the endothelium and is associated with increased arterial stiffness in ANCA-associated vasculitis

Arthritis Research & Therapy
Dimitrios ChanouzasL Harper

Abstract

Cardiovascular disease is a leading cause of death in ANCA-associated vasculitis (AAV). An expansion of CD4+CD28null T cells is seen mainly in cytomegalovirus (CMV)-seropositive individuals and has been linked to increased cardiovascular disease risk in other conditions. The aims of this study were to phenotype CD4+CD28null T cells in AAV with respect to their pro-inflammatory capacity and ability to target and damage the endothelium and to investigate their relationship to arterial stiffness, a marker of cardiovascular mortality. CD4+CD28null T cells were phenotyped in 53 CMV-seropositive AAV patients in stable remission and 30 age-matched CMV-seropositive healthy volunteers by flow cytometry following stimulation with CMV lysate. The expression of endothelial homing markers and cytotoxic molecules was evaluated in unstimulated CD4+CD28null T cells. Arterial stiffness was measured by carotid-to-femoral pulse wave velocity (PWV) in patients with AAV. CD4+CD28null T cells were CMV-specific and expressed a T helper 1 (Th1) phenotype with high levels of interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α) secretion. They also co-expressed the endothelial homing markers CX3CR1, CD49d and CD11b and cytotoxic molecules p...Continue Reading

References

May 1, 1996·The Journal of Clinical Investigation·D SchmidtC M Weyand
Aug 5, 2000·Virchows Archiv : an International Journal of Pathology· Pampou SYuM E DeBakey
Feb 6, 2002·Circulation·Takako NakajimaCornelia M Weyand
Sep 5, 2002·Arthritis and Rheumatism·Nicola J GoodsonDeborah P M Symmons
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chiara BuonoAndrew H Lichtman
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Nov 1, 2005·Journal of the American College of Cardiology·Carmel M McEnieryUNKNOWN ACCT Investigators
Apr 5, 2007·Nature Protocols·Pratip K ChattopadhyayMario Roederer
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marielle ThewissenPiet Stinissen
Dec 4, 2008·Journal of Lipid Research·Ziad MallatAlain Tedgui
Apr 22, 2010·Heart·Colin D ChueCharles J Ferro
Apr 30, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sheri Lewis BateMichael J Cannon
Jun 10, 2010·European Heart Journal·UNKNOWN Reference Values for Arterial Stiffness' Collaboration
Nov 27, 2010·Annals of the Rheumatic Diseases·Oliver FlossmannUNKNOWN European Vasculitis Study Group
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Hafid Ait-OufellaAlain Tedgui
Dec 3, 2011·Journal of Nephrology·Michiel G H BetjesNicolle H R Litjens
Mar 9, 2012·Clinical and Vaccine Immunology : CVI·Pablo J E J van de BergIneke J M ten Berge
Apr 26, 2015·Journal of Clinical Lipidology·W Virgil BrownPaul M Ridker
Aug 2, 2015·Journal of Leukocyte Biology·Patricia LópezAna Suarez
Nov 26, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S ShabirR Borrows
Apr 14, 2016·QJM : Monthly Journal of the Association of Physicians·C FirthP Moss
Aug 29, 2017·The New England Journal of Medicine·Paul M RidkerUNKNOWN CANTOS Trial Group

❮ Previous
Next ❯

Citations

Apr 8, 2020·Acta Biochimica Et Biophysica Sinica·Wenbo Zhu, Shuangquan Liu
Jul 31, 2019·Current Opinion in Nephrology and Hypertension·Luke PickupCharles J Ferro
May 14, 2020·Expert Opinion on Biological Therapy·Sei MuraokaToshihiro Nanki
Oct 16, 2019·QJM : Monthly Journal of the Association of Physicians·A H K KarangiziL Harper
Mar 13, 2020·GeroScience·Janko Nikolich-ŽugichNiels Lemmermann
Aug 29, 2020·Nature Reviews. Disease Primers·A Richard KitchingRenate Kain
Jan 17, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·David BoutolleauShaida Varnous
Feb 26, 2021·Journal of Medical Virology·Agnieszka JabłońskaIhor Huk

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
enzyme-linked immunosorbent assay

Software Mentioned

ProcartaPlex Analyst
FACS DIVA
SPSS Statistics
Prism

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.