Jan 8, 2015

The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis

Frontiers in Oncology
Sourik S GangulyCindy K Miranti

Abstract

Prostate cancer (PCa) is the second leading cause of cancer death in men worldwide. Most PCa deaths are due to osteoblastic bone metastases. What triggers PCa metastasis to the bone and what causes osteoblastic lesions remain unanswered. A major contributor to PCa metastasis is the host microenvironment. Here, we address how the primary tumor microenvironment influences PCa metastasis via integrins, extracellular proteases, and transient epithelia-mesenchymal transition (EMT) to promote PCa progression, invasion, and metastasis. We discuss how the bone-microenvironment influences metastasis; where chemotactic cytokines favor bone homing, adhesion molecules promote colonization, and bone-derived signals induce osteoblastic lesions. Animal models that fully recapitulate human PCa progression from primary tumor to bone metastasis are needed to understand the PCa pathophysiology that leads to bone metastasis. Better delineation of the specific processes involved in PCa bone metastasize is needed to prevent or treat metastatic PCa. Therapeutic regimens that focus on the tumor microenvironment could add to the PCa pharmacopeia.

Mentioned in this Paper

Prostatic Neoplasms
Extracellular
Bulla
Primary Neoplasm
Peptide Hydrolases
Endopeptidases
Chemokine
Proteolytic Enzyme
Prostate Carcinoma
Secondary Malignant Neoplasm of Bone

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Jung-Kang JinGary E Gallick
Journal of Mammary Gland Biology and Neoplasia
Donald E White, William J Muller
Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society
Anjali MishraRussell S Taichman
Cellular and Molecular Life Sciences : CMLS
E K I Sloan, R L Anderson
© 2020 Meta ULC. All rights reserved