The HSP70 chaperone machinery: J proteins as drivers of functional specificity.

Nature Reviews. Molecular Cell Biology
Harm H Kampinga, Elizabeth A Craig

Abstract

Heat shock 70 kDa proteins (HSP70s) are ubiquitous molecular chaperones that function in a myriad of biological processes, modulating polypeptide folding, degradation and translocation across membranes, and protein-protein interactions. This multitude of roles is not easily reconciled with the universality of the activity of HSP70s in ATP-dependent client protein-binding and release cycles. Much of the functional diversity of the HSP70s is driven by a diverse class of cofactors: J proteins. Often, multiple J proteins function with a single HSP70. Some target HSP70 activity to clients at precise locations in cells and others bind client proteins directly, thereby delivering specific clients to HSP70 and directly determining their fate.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H J HoffmannH Echols
Aug 1, 1989·Trends in Biochemical Sciences·R J Ellis, S M Hemmingsen
Jul 5, 1987·Nature·J Ellis
Aug 1, 1984·The Journal of Cell Biology·W A BraellJ E Rothman
May 26, 1995·Journal of Molecular Biology·J S McCartyB Bukau
Mar 3, 1995·International Journal of Cancer. Journal International Du Cancer·M Jäättelä
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SzaboF U Hartl
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·N B RadfordR S Williams
Jul 12, 1996·Journal of Molecular Biology·M PellecchiaK Wüthrich
Mar 1, 1996·Current Biology : CB·T ZiegelhofferE A Craig
Nov 1, 1996·Molecular and Cellular Biology·V PrapapanichD F Smith
Jan 31, 1998·The Journal of Biological Chemistry·A A MichelsH H Kampinga
May 19, 1998·Cell Stress & Chaperones·M E Cheetham, A J Caplan
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M K GreeneS J Landry
Aug 26, 1998·The EMBO Journal·W YanE A Craig
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·W C SuhC A Gross
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·C S GässlerB Bukau
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·T LaufenB Bukau
May 21, 1999·The Journal of Biological Chemistry·H J OhJ R Subjeck
Jan 11, 2000·Molecular and Cellular Biology·E A NollenR I Morimoto
Mar 10, 2000·Science·P Kazemi-Esfarjani, S Benzer
Nov 15, 2000·The Journal of Biological Chemistry·E A NollenH H Kampinga
Dec 22, 2000·Journal of Molecular Biology·J R Cupp-Vickery, L E Vickery
Jan 9, 2001·Nature Cell Biology·G C MeachamD M Cyr
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·C VoisineE A Craig
Mar 27, 2001·The Journal of Cell Biology·J L Johnson, E A Craig

❮ Previous
Next ❯

Citations

Aug 6, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Martin GamerdingerChristian Behl
Mar 1, 2012·Molecular Neurobiology·Tobias MoraweChristian Behl
Aug 30, 2011·Cell Stress & Chaperones·Jordan Thomas Silver, Earl G Noble
Nov 20, 2012·Cell Stress & Chaperones·Neelam K SarkarAnil Grover
Jul 27, 2012·Expert Reviews in Molecular Medicine·Matthew C Smith, Jason E Gestwicki
Nov 26, 2010·Parasitology·Aleksandar ZocevicPascal Boireau
Jun 20, 2012·ACS Chemical Biology·Sidhartha M ChafekarMartin L Duennwald
Aug 22, 2012·Journal of Proteome Research·Anja RosenowJohan Renes
Sep 13, 2013·Nature Reviews. Molecular Cell Biology·Helen Saibil
Sep 26, 2013·Nature Reviews. Molecular Cell Biology·Shannon M DoyleSue Wickner
Jan 11, 2011·Nature Structural & Molecular Biology·Moritz MarcinowskiJohannes Buchner
Dec 4, 2012·Nature Structural & Molecular Biology·Christoph LeidigIrmgard Sinning
Jun 27, 2012·Molecular BioSystems·Sharan R SrinivasanJason E Gestwicki
Aug 2, 2012·Molecular BioSystems·Anne T GilliesJason E Gestwicki
May 1, 2013·Molecular BioSystems·Johan Renes, Edwin Mariman
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Donna M HurynPeter Wipf
Apr 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marika MiotSue Wickner
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Deepak Sharma, Daniel C Masison
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Atta AhmadErik R P Zuiderweg
Aug 13, 2011·The Journal of Biological Chemistry·Samantha PembertonRonald Melki
Apr 12, 2012·The Journal of Biological Chemistry·Melissa A ScrantonLinda L Walling
Mar 1, 2012·The Journal of Biological Chemistry·Anushikha ThakurPatrick D'Silva
Oct 24, 2012·The Journal of Biological Chemistry·Imad BaakliniJason C Young
Aug 24, 2013·The Journal of Biological Chemistry·Christian BergmayrChristian W Gruber
Dec 15, 2011·Molecular & Cellular Proteomics : MCP·Kirti SharmaF Ulrich Hartl
Jun 24, 2011·Molecular Biology of the Cell·Yoshihiro MatsumuraWilliam R Skach
Jul 22, 2011·Molecular Biology of the Cell·Xingqian Zhang, Shu-Bing Qian
Feb 1, 2013·Molecular Biology of the Cell·Jeffrey M WilliamsBilly Tsai
Apr 26, 2013·Molecular Biology of the Cell·Marta A UzarskaUlrich Mühlenhoff
Jul 19, 2013·Molecular Biology of the Cell·Lena BöttingerThomas Becker
Aug 28, 2012·Bioinformatics·Ratheesh Kumar RPatrick D'Silva
Mar 8, 2012·Brain : a Journal of Neurology·John LabbadiaMichael E Cheetham
Mar 16, 2012·Genome Biology and Evolution·David BogumilTal Dagan
Nov 28, 2013·Genome Biology and Evolution·Jacek KominekBarry L Williams
Sep 17, 2010·Human Molecular Genetics·Michel J VosHarm H Kampinga

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Atta AhmadErik R P Zuiderweg
Proceedings of the National Academy of Sciences of the United States of America
Chandan Sahi, Elizabeth A Craig
Cellular and Molecular Life Sciences : CMLS
M P Mayer, B Bukau
© 2021 Meta ULC. All rights reserved