The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts

Human Molecular Genetics
M AldersM Mannens

Abstract

Here we describe the cloning of the human Achaete Scute Homologue 2 (HASH2) gene, officially designated ASCL2 (Achaete Scute complex like 2), a homologue of the Drosophila Achaete and Scute genes. In mouse, this gene is imprinted and maps to chromosome 7. We mapped the human homologue close to IGF2 and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly conserved in mouse and man. HASH2 is expressed in the extravillus trophoblasts of the developing placenta only. The lack of HASH2 expression in non-malignant hydatidiform (androgenetic) moles indicates that HASH2 is also imprinted in man.

References

Apr 1, 1992·Nature Genetics·Y Zhang, B Tycko
Jul 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I J Van WijkC B Oudejans
Sep 22, 1994·Nature·F GuillemotA L Joyner
May 1, 1994·Gynecologic Oncology·I ArielA Hochberg
Sep 1, 1993·Genomics·M W SmithY Lin
Apr 22, 1993·Nature·S RainierA P Feinberg
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·J M HooversA P Feinberg
Jun 1, 1996·Human Molecular Genetics·I HatadaT Mukai
Apr 1, 1964·The Journal of Obstetrics and Gynaecology of the British Commonwealth·D CHUNL LOK

❮ Previous
Next ❯

Citations

Mar 30, 2000·Genes, Chromosomes & Cancer·M SteenmanM Mannens
Jul 19, 2002·Journal of Cellular Physiology·Benjamin Tycko, Ian M Morison
Apr 20, 2005·Placenta·P M CoanA C Ferguson-Smith
Feb 24, 2001·Theriogenology·J C Cross
May 14, 1999·Trends in Ecology & Evolution·H G SpencerM W Feldman
Feb 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C OudejansM Mannens
Apr 11, 2001·Trends in Endocrinology and Metabolism : TEM·M Hemberger, J C Cross
May 12, 1998·Molecular Medicine Today·I M Morison, A E Reeve
Mar 11, 1999·Human Molecular Genetics·M P LeeA P Feinberg
Apr 1, 2006·Cytogenetic and Genome Research·B Tycko
Jul 9, 2004·Reproductive Biology and Endocrinology : RB&E·R Michael RobertsPadmalaya Das
May 25, 2011·The Journal of Reproduction and Development·Hanako BaiKazuhiko Imakawa
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·John M Greally
Apr 29, 1999·Annals of Medicine·M Mannens, M Alders
Jun 27, 2007·American Journal of Medical Genetics. Part a·W P RobinsonD E McFadden
Oct 12, 2004·Genomics·Marianne JonssonJulia Asp
Mar 18, 1999·The American Journal of Pathology·J G FallsR L Jirtle
Nov 28, 2000·Annual Review of Genetics·H G Spencer
Sep 12, 2006·Developmental Biology·Motoko AokiHitoshi Okamoto
Jun 30, 2000·Seminars in Cell & Developmental Biology·J C Cross
Feb 25, 2003·Placenta·J C CrossJ C P Kingdom
Jan 1, 2011·Clinical Epigenetics·L Serman, D Dodig
Oct 29, 2013·Trends in Genetics : TIG·Ronald M NelsonÖrjan Carlborg
Mar 29, 2014·Journal of Veterinary Science·Jongki ChoByeong Chun Lee
Feb 27, 2018·Biology of Reproduction·Michael J SoaresKhursheed Iqbal
Jul 4, 2001·Nature Reviews. Genetics·J Rossant, J C Cross
Jul 11, 2001·Genome Génome / Conseil National De Recherches Canada·A K NaumovaK Morgan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.