The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities

Proceedings of the National Academy of Sciences of the United States of America
Zuzana KeckesovaGreg J Towers

Abstract

The rhesus macaque tripartite motif containing protein TRIM5alpha specifically restricts HIV-1 infection at an early post-entry step before reverse transcription [Stremlau, M., Owens, C. M., Perron, M. J., Kiessling, M., Autissier, P. & Sodroski, J. (2004) Nature 427, 848-853]. Here, we show that the human and African green monkey (AGM) TRIM5alpha genes encode Ref1 and Lv1 antiretroviral activities, respectively. Expression of TRIM5alpha in permissive cat cells renders them resistant to restriction-sensitive murine leukemia virus but not closely related insensitive virus. Disruption of TRIM5alpha expression in human and AGM cells with small interfering RNA rescues infectivity of restricted virus without affecting unrestricted virus. We also demonstrate that the activity of the murine restriction factor Fv1 depends on TRIM5alpha expression when Fv1 is expressed in human cells. Furthermore, a drug that modifies the behavior of the related promyelocytic leukemia protein PML specifically rescues infection by viruses restricted by human TRIM5alpha. Alignment of the TRIM5alpha proteins from rhesus macaque and AGM indicates an 18-aa insertion. We speculate that this insertion may contribute to the broader specificity of the AGM TRIM5a...Continue Reading

References

May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W K YangR H Bassin
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·J ZhuH de Thé
May 1, 1999·Proteins·M H SetoM Whitlow
Nov 13, 1999·Journal of Virology·W HofmannJ Sodroski
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·G TowersO Danos
Feb 12, 2002·Journal of Virology·Greg TowersYasuhiro Takeuchi
Jul 27, 2002·Annual Review of Genomics and Human Genetics·Michael DeanStephen J O'Brien
Aug 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simone CowanPaul D Bieniasz
Aug 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Caroline BesnierGreg Towers
Sep 5, 2002·Nature Reviews. Cancer·Jun ZhuHugues de Thé
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Carsten MünkNathaniel R Landau
Oct 25, 2002·AIDS Research and Human Retroviruses·Otto O YangJanis V Giorgi
Feb 14, 2003·Journal of Virology·Lionel BerthouxJeremy Luban
May 17, 2003·Science·Denise LecossierAllan J Hance
Jun 18, 2003·Cell·Reuben S HarrisMichael H Malim
Jun 26, 2003·Trends in Microbiology·Paul D Bieniasz
Jul 16, 2003·Cell·Roberto MarianiNathaniel R Landau
Aug 5, 2003·Nature Medicine·Greg J TowersPaul D Bieniasz
Oct 7, 2003·Nature Medicine·Mariana MarinDavid Kabat
Nov 18, 2003·Traffic·Sean D ConnerSandra L Schmid
Dec 3, 2003·Journal of Virology·Caroline BesnierGreg J Towers
Dec 25, 2003·Journal of Virology·Theodora HatziioannouPaul D Bieniasz
Feb 14, 2004·Journal of Virology·Ryan Hagglund, Bernard Roizman
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bärbel SchröfelbauerNathaniel R Landau

❮ Previous
Next ❯

Citations

Mar 9, 2006·Current HIV/AIDS Reports·Omar Perez, Thomas J Hope
Jan 23, 2010·Journal of the American Chemical Society·Yun HanTatyana Polenova
Mar 1, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mayumi OaklandPaul B McCray
Oct 22, 2004·Nature Immunology·Paul D Bieniasz
Aug 3, 2004·Nature Medicine·Warner C Greene
Sep 22, 2005·Nature Reviews. Microbiology·Sébastien NisoleAli Saïb
Mar 13, 2012·Nature Structural & Molecular Biology·Matthew E C CainesLeo C James
Nov 18, 2005·Gene Therapy·J L Anderson, T J Hope
Feb 15, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maarten A N RitsNeeltje A Kootstra
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sam J WilsonGreg J Towers
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cesar A VirgenTheodora Hatziioannou
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Harriet C T GroomKate N Bishop
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Steven J SollPaul D Bieniasz
Jan 8, 2010·The Journal of Biological Chemistry·Chae Young HwangByeongwoon Song
Sep 3, 2010·The Journal of Biological Chemistry·Seiga OhmineYasuhiro Ikeda
Dec 21, 2010·The Journal of Biological Chemistry·Pierre V MaillardDidier Trono
Nov 26, 2008·The Journal of Biological Chemistry·Chuanxi CaiJianjie Ma
Apr 12, 2012·Molecular & Cellular Proteomics : MCP·Jonathan WoodsmithChris M Sanderson
Jan 21, 2011·AIDS Research and Human Retroviruses·Jaya Sastri, Edward M Campbell
Oct 13, 2005·Human Gene Therapy·Greg J Towers
Aug 22, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Stuart Neil, Paul Bieniasz
Mar 30, 2007·Molecular Biology of the Cell·Edward M CampbellThomas J Hope
Nov 26, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Feng-Liang LiuYong-Tang Zheng
Aug 14, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Melvyn W Yap, Jonathan P Stoye
May 4, 2012·Cold Spring Harbor Perspectives in Medicine·Michael H Malim, Paul D Bieniasz
Jul 5, 2007·Journal of Virology·Yuko MorikawaTetsuro Matano
Apr 23, 2010·Journal of Virology·Lesa R Black, Christopher Aiken
Apr 18, 2008·Journal of Virology·Zerina KratovacTheodora Hatziioannou
May 14, 2010·Journal of Virology·Melissa A SternEric M Poeschla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Theodora HatziioannouPaul D Bieniasz
Proceedings of the National Academy of Sciences of the United States of America
Melvyn W YapJ P Stoye
Proceedings of the National Academy of Sciences of the United States of America
Michel PerronJoseph Sodroski
© 2022 Meta ULC. All rights reserved