The human ATP-binding cassette transporter genes: from the bench to the bedside

Current Molecular Medicine
T Efferth

Abstract

ATP-binding cassette (ABC) transporter genes are ubiquitously present in most organisms from bacteria to man. This gene family is the largest one known as of yet. Still growing, the number of human ABC transporters counts currently 47 members which belong to seven subfamilies. ABC transporters share a similar molecular architecture: (1) Full-structured transporters harbor two symmetric halves each consisting of one nucleotide binding domain (NBD) and one transmembrane domain (TMD). (2) Half-transporters with one NBD and one TMD homo- or heterodimerize to functional transporter complexes. ABC transporters are "traffic ATPases" which hydrolyze ATP and which transport a wide array of molecules or conduct the transport of molecules by stimulating other translocation mechanisms. Many ABC transporters are involved in human inherited or sporadic diseases such as cystic fibrosis, adrenoleukodystrophy, Stargardt's disease, drug-resistant tumors, Dubin-Johnson syndrome, Byler's disease, progressive familiar intrahepatic cholestasis, X-linked sideroblastic anemia and ataxia, persistent hyperinsulimenic hypoglycemia of infancy, and others. The present review summarizes the current findings in basic research and the efforts for bridging the...Continue Reading

Citations

May 14, 2005·Pharmacology & Therapeutics·Thomas Efferth, Manfred Volm
Aug 9, 2003·Biochemical Pharmacology·Thomas EfferthAxel Sauerbrey
Jun 8, 2011·Radiation Oncology·Thomas Efferth, Peter Langguth
Dec 17, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Xin GuoYuan-Jian Li
Apr 11, 2012·International Journal of Molecular Sciences·Shuwen YuFengshan Wang
Feb 22, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mohamed SaeedThomas Efferth
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Victor KueteThomas Efferth
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mohamed SaeedThomas Efferth
Nov 1, 2006·Expert Opinion on Drug Discovery·Janos Nadas, Duxin Sun
Feb 11, 2010·Chemico-biological Interactions·Serkan SertelThomas Efferth
Jul 15, 2015·Journal of Ethnopharmacology·Mohamed E M SaeedThomas Efferth
Dec 15, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Victor KueteThomas Efferth
Oct 27, 2015·Future Medicinal Chemistry·Elisabeta BaiceanuPierre Falson
Jul 16, 2010·Journal of Cellular and Molecular Medicine·Shahid SoomroThomas Efferth
Mar 15, 2006·Yi chuan xue bao = Acta genetica Sinica·Yan-Hong LiLing Yang
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Jun 15, 2014·Journal of Ethnopharmacology·Chanai NoysangThomas Efferth
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Jun 19, 2007·Biochimica Et Biophysica Acta·Jean-Pierre GilletJosé Remacle

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