The human brain is intrinsically organized into dynamic, anticorrelated functional networks

Proceedings of the National Academy of Sciences of the United States of America
Michael D FoxMarcus E Raichle

Abstract

During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity. In this study, we investigate the extent to which this task-related dichotomy is represented intrinsically in the resting human brain through examination of spontaneous fluctuations in the functional MRI blood oxygen level-dependent signal. We identify two diametrically opposed, widely distributed brain networks on the basis of both spontaneous correlations within each network and anticorrelations between networks. One network consists of regions routinely exhibiting task-related activations and the other of regions routinely exhibiting task-related deactivations. This intrinsic organization, featuring the presence of anticorrelated networks in the absence of overt task performance, provides a critical context in which to understand brain function. We suggest that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain.

References

Feb 1, 1970·Transactions of the New York Academy of Sciences·J S AntrobusM Fortgang
Sep 1, 1995·Memory & Cognition·J D TeasdaleA D Baddeley
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Sep 11, 1999·Neuron·E Wojciulik, N Kanwisher
Apr 19, 2000·Journal of Cognitive Neuroscience·R Cabeza, L Nyberg
Sep 28, 2000·Trends in Neurosciences·J Duncan, A M Owen
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J R SimpsonM E Raichle
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J R SimpsonM E Raichle
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A GusnardM E Raichle
Apr 3, 2001·Nature Reviews. Neuroscience·F VarelaJ Martinerie
Sep 15, 2001·Science·J D GreeneJ D Cohen
Oct 5, 2001·Nature Reviews. Neuroscience·D A GusnardM E Raichle
Oct 5, 2001·Nature Reviews. Neuroscience·A K EngelW Singer
Feb 9, 2002·Human Brain Mapping·Michelle HampsonJohn C Gore
Apr 24, 2002·Journal of Cognitive Neuroscience·Maurizio CorbettaGordon L Shulman
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
May 6, 2003·Journal of Cognitive Neuroscience·Kristen A McKiernanJeffrey R Binder
Jun 20, 2003·NeuroImage·Vesa KiviniemiOsmo Tervonen
Sep 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·H LaufsA Kleinschmidt
Sep 12, 2003·Cerebral Cortex·Sonja Rakic, Nada Zecevic
Apr 20, 2004·Neuroreport·Deborah L KerrMarcus E Raichle
Jun 26, 2004·Science·György Buzsáki, Andreas Draguhn
Sep 24, 2004·Human Brain Mapping·Anthony B WaitesGraeme D Jackson
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin J Shannon, Randy L Buckner
Dec 17, 2004·Journal of Cognitive Neuroscience·Michael D Greicius, Vinod Menon
Oct 1, 1997·Journal of Cognitive Neuroscience·G L ShulmanS E Petersen

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Citations

Apr 8, 2009·Archives of General Psychiatry·L Elliot HongElliot A Stein
May 11, 2011·Archives of Neurology·Mary M MachuldaClifford R Jack
Feb 8, 2013·JAMA Psychiatry·Jonathan PosnerBradley S Peterson
Dec 17, 2008·Neurotoxicity Research·Tomas PalomoTrevor Archer
Sep 24, 2010·Psychopharmacology·Matthew T SutherlandElliot A Stein
Dec 15, 2010·Psychopharmacology·Michael J MinzenbergCameron S Carter
May 1, 2009·Experimental Brain Research·Christina E HugenschmidtPaul J Laurienti
Nov 26, 2010·Experimental Brain Research·Xiaodan YanXuchu Weng
May 10, 2011·Neuroradiology·Paritosh C KhannaDennis W W Shaw
Mar 14, 2012·Pediatric Radiology·Ashok PanigrahyStefan Bluml
Feb 27, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Marc WermkeAlexander Drzezga
Dec 1, 2006·Biological cybernetics·Mikhail I RabinovichValentin S Afraimovich
Jun 1, 2010·Brain Structure & Function·Steven M NelsonSteven E Petersen
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Sep 21, 2010·Brain Structure & Function·Shella D KeilholzGarth Thompson
Jul 5, 2012·Brain Structure & Function·Nasim MalekiDavid Borsook
Oct 12, 2012·Brain Structure & Function·Massimo FilippiMaria A Rocca
Sep 9, 2011·Der Schmerz·A Otti, M Noll-Hussong
Oct 18, 2011·Journal of Neural Transmission·L KrajcovicovaIrena Rektorova
Jan 31, 2012·European Child & Adolescent Psychiatry·María Ángeles MairenaF Xavier Castellanos
Jun 15, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Cristina Rosazza, Ludovico Minati
Jun 4, 2010·Magma·Veronika SchöpfEwald Moser
May 18, 2010·Magma·Philipp G SämannMichael Czisch
Aug 10, 2006·Cognitive Processing·Carlo Sestieri, Maurizio Corbetta
Oct 31, 2009·Cognitive Processing·Klaus B BaerentsenAnders C Green
Oct 12, 2012·Breast Cancer Research and Treatment·Patricia A Reuter-Lorenz, Bernadine Cimprich
Oct 27, 2010·Neuropsychology Review·Alecia C VogelBradley L Schlaggar
Aug 12, 2014·Psychometrika·Douglas N GreveUNKNOWN Function Biomedical Research Network
Jul 25, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Karen D Davis, Massieh Moayedi
Sep 8, 2010·Bulletin of Mathematical Biology·Moira L Steyn-RossM T Wilson
Sep 8, 2010·Bulletin of Mathematical Biology·Valentin AfraimovichMikhail I Rabinovich
Nov 13, 2008·Cognitive Neurodynamics·Gerhard Werner

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