The human c1q globular domain: structure and recognition of non-immune self ligands.

Frontiers in Immunology
Christine GaboriaudGérard J Arlaud

Abstract

C1q, the ligand-binding unit of the C1 complex of complement, is a pattern recognition molecule with the unique ability to sense an amazing variety of targets, including a number of altered structures from self, such as apoptotic cells. The three-dimensional structure of its C-terminal globular domain, responsible for its recognition function, has been solved by X-ray crystallography, revealing a tightly packed heterotrimeric assembly with marked differences in the surface patterns of the subunits, and yielding insights into its versatile binding properties. In conjunction with other approaches, this same technique has been used recently to decipher the mechanisms that allow this domain to interact with various non-immune self ligands, including molecules known to provide eat-me signals on apoptotic cells, such as phosphatidylserine and DNA. These investigations provide evidence for a common binding area for these ligands located in subunit C of the C1q globular domain, and suggest that ligand recognition through this area down-regulates C1 activation, hence contributing to the control of the inflammatory reaction. The purpose of this article is to give an overview of these advances which represent a first step toward understan...Continue Reading

Citations

Jan 6, 2016·Biochemistry·Miho ChikazawaKoji Uchida
Sep 28, 2015·Immunologic Research·Myoungsun SonFrances Santiago-Schwarz
Jun 18, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Jun 24, 2014·Molecular Immunology·Anna M DaviesBrian J Sutton
Nov 22, 2014·Frontiers in Immunology·Christine GaboriaudVéronique Rossi
Jun 10, 2017·Frontiers in Immunology·Jinhua Lu, Uday Kishore
Apr 8, 2020·Frontiers in Immunology·Uday Kishore, Berhane Ghebrehiwet
Jan 27, 2017·Oncoimmunology·Silvio BandiniFederica Cavallo
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Mar 23, 2018·Frontiers in Immunology·Mickaël JacquetVéronique Rossi
Apr 1, 2020·Cellular & Molecular Biology Letters·Mehri Bemani NaeiniAmirhossein Sahebkar
Jun 3, 2021·International Journal of Molecular Sciences·Guillaume FouëtVéronique Rossi
May 23, 2017·Nano Letters·M Saint-CricqW L Ling

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Methods Mentioned

BETA
X-ray
Surface plasmon resonance
Electrophoretic mobility shift assay

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