The human chorionic gonadotropin molecule from patients with trophoblastic diseases has a high thyrotropic activity but is less active in the ovary

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
K KatoR Hoermann

Abstract

To examine the pathogenesis of hyperthyroidism in women with trophoblastic diseases, the biological activity of human chorionic gonadotropin (hCG) molecules in women with normal pregnancy (n = 85) and in women with trophoblastic diseases (vesicular mole, n = 30; and choriocarcinoma, n = 12) was compared. Hyperthyroidism (thyroid stimulating hormone (TSH) < 0.3 mIU/l) was observed more frequently in women with trophoblastic diseases. All the sera were then subjected to Chinese hamster ovary cells transfected with the human TSH receptor (CHO-hTSHr cells) and cAMP production was compared. Sera from the women with choriocarcinoma showed the highest cAMP production. Interestingly, significant correlation between serum hCG level and cAMP production in CHO-hTSHr cells was observed only in women with trophoblastic disease. All the sera were then applied to CHO cells transfected with hCG/luteinizing hormone (LH) receptor (CHO-hCG/LHr cells). In contrast to the findings with the TSH receptor, sera from the women with normal pregnancy showed the highest cAMP production in these cells. Correlation between serum hCG level and cAMP production in CHO-hCG/LHr cells was significant only in normal pregnancy. These results indicate that the hCG m...Continue Reading

References

Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J G KenimerH P Higgins
Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·M YoshimuraM Inada
Feb 1, 1992·The Journal of Clinical Endocrinology and Metabolism·J M Hershman
Jan 1, 1995·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·S PoertlR Hoermann
Dec 5, 1996·The New England Journal of Medicine·R S Berkowitz, D P Goldstein
Mar 1, 1997·Clinical Obstetrics and Gynecology·T M Goodwin, J M Hershman
Jun 1, 1997·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·R A FoulkR N Taylor
Dec 2, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R NishimuraH Yasui
Jan 26, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·N SakaguchiM Inada
Feb 11, 1999·Molecular Endocrinology·A SchulzT Gudermann
Jul 13, 2000·Lancet·M J SecklE S Newlands
Sep 6, 2000·Clinical Endocrinology·J H Lazarus, A Kokandi
Jul 17, 2001·Clinical Endocrinology·J A TalbotW R Robertson
Apr 1, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R NishimuraH Yasui

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Citations

Sep 3, 2008·Archives of Gynecology and Obstetrics·S A Mousavi, F Behnamfar
Jun 10, 2009·Thyroid : Official Journal of the American Thyroid Association·Christina M LockwoodAnn M Gronowski
Feb 1, 2013·Journal of Thyroid Research·Johannes W DietrichElisavet H Fotiadou
Dec 5, 2015·Frontiers in Endocrinology·Rudolf HoermannJohannes W Dietrich
Jul 22, 2008·Archives of Gynecology and Obstetrics·Lena StruthmannIoannis Mylonas
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·John H Lazarus, Myrto Kaklamanou
Apr 18, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shigeo Iijima
Feb 1, 2012·Archives of Pathology & Laboratory Medicine·Ruthy Shaco-LevyStanley J Robboy
Feb 25, 2009·Immunopharmacology and Immunotoxicology·Annalisa RizzoRaffaele Sciorsci
Jul 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yeşim ErbilSelçuk Ozarmağan
Mar 11, 2005·Current Opinion in Obstetrics & Gynecology·Terence T Lao
Jan 16, 2021·Thyroid Research·Jarett Vanz-Brian Pereira, Taylor Lim
Jan 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Erik S MittraI Ross McDougall

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