The human CSF pain proteome

Journal of Proteomics
Payam Emami KhoonsariJon Lampa

Abstract

Chronic pain represents one of the major medical challenges in the 21st century, affecting >1.5 billion of the world population. Overlapping and heterogenous symptoms of various chronic pain conditions complicate their diagnosis, emphasizing the need for more specific biomarkers to improve the diagnosis and understand the disease mechanisms. We have here investigated proteins found in human CSF with respect to known "pain" genes and in a cohort of patients with dysfunctional pain (fibromyalgia, FM), inflammatory pain (rheumatoid arthritis patients, RA) and non-pain controls utilized semi-quantitative proteomics using mass spectrometry (MS) to explore quantitative differences between these cohorts of patients. We found that "pain proteins" detected in CSF using MS are typically related to synaptic transmission, inflammatory responses, neuropeptide signaling- and hormonal activity. In addition, we found ten proteins potentially associated with chronic pain in FM and RA: neural cell adhesion molecule L1, complement C4-A, lysozyme C, receptor-type tyrosine-protein phosphatase zeta, apolipoprotein D, alpha-1-antichymotrypsin, granulins, calcium/calmodulin-dependent protein kinase type II subunit alpha, mast/stem cell growth factor r...Continue Reading

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Citations

Jul 21, 2020·Expert Review of Proteomics·Björn Gerdle, Bijar Ghafouri
Jan 11, 2020·Frontiers in Neuroscience·John ManionG Gregory Neely
Nov 22, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jonathan RoydsConnail McCrory
Feb 20, 2021·Biochemistry·Minji JeonAvi Ma'ayan
Mar 20, 2020·Current Opinion in Behavioral Sciences·Bianka KarshikoffIhssane Zouikr
Jul 17, 2021·Current Pain and Headache Reports·Kristen MathiasAlaa Abd-Elsayed
Oct 26, 2021·Frontiers in Physiology·Diego Sanchez, Maria D Ganfornina

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