The human cutaneous chemokine system.

Frontiers in Immunology
Michelle L McCully, Bernhard Moser

Abstract

Irrespective of the immune status, the vast majority of all lymphocytes reside in peripheral tissues whereas those present in blood only amount to a small fraction of the total. It has been estimated that T cells in healthy human skin outnumber those present in blood by at least a factor of two. How lymphocytes within these two compartments relate to each other is not well understood. However, mounting evidence suggest that the study of T cell subsets present in peripheral blood does not reflect the function of their counterparts at peripheral sites. This is especially true under steady-state conditions whereby long-lived memory T cells in healthy tissues, notably those in epithelial tissues at body surfaces, are thought to fulfill a critical immune surveillance function by contributing to the first line of defense against a series of local threats, including microbes, tumors, and toxins, and by participating in wound healing. The relative scarcity of information regarding peripheral T cells and the factors regulating their localization is primarily due to inherent difficulties in obtaining healthy tissue for the extraction and study of immune cells on a routine basis. This is most certainly true for humans. Here, we review our...Continue Reading

Citations

Sep 3, 2013·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Osamu Yoshie
Jun 17, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Fang WangXingqi Zhang
Sep 28, 2013·Expert Opinion on Therapeutic Targets·Tej Pratap SinghJoshua M Farber
Sep 4, 2016·British Journal of Pharmacology·E StephensonF M Marelli-Berg
Jun 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Rocky LaiZhou Xing
Apr 13, 2019·Immunological Reviews·Jillian M RichmondJohn E Harris
Aug 25, 2018·Oncotarget·Kashif RasheedUgo Moens
Apr 1, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paul J CollinsBernhard Moser
Dec 24, 2018·Journal of Leukocyte Biology·Le-Xun WangJiao Guo
Nov 14, 2020·Anesthesia and Analgesia·Andreas MargrafJan Rossaint

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Methods Mentioned

BETA
genetic modifications

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