PMID: 9188570Jul 1, 1997Paper

The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection

Journal of Virology
Andrew D YurochkoE S Huang

Abstract

The cellular transcription factors Sp1 and NF-kappaB were upregulated shortly after the binding of purified live or UV-inactivated human cytomegalovirus (HCMV) to the cell surface. The rapid time frame of transcription factor induction is similar to that seen in other systems in which cellular factors are induced following receptor-ligand engagement. This similarity suggested that a cellular receptor-viral ligand interaction might be involved in Sp1 and NF-kappaB activation during the earliest stages of HCMV infection. To focus on the possible role viral ligands play in initiating cellular events following infection, we first used purified viral membrane extracts to demonstrate that constituents on the membrane are responsible for cellular activation. Additionally, these studies showed, through the use of neutralizing antibodies, that the viral membrane mediators of this activation are the major envelope glycoproteins gB (UL55) and gH (UL75). To confirm these results, neutralizing anti-gB and -gH antibodies were used to block the interactions of these glycoproteins on whole purified virus with their cell surface receptors. In so doing, we found that Sp1 and NF-kappaB induction was inhibited. Lastly, through the use of purified ...Continue Reading

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Citations

Jun 7, 2002·Journal of Virology·Dool-Bboon Kim, Neal A DeLuca
Sep 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Edward P Browne, Thomas Shenk
Sep 12, 2013·Bipolar Disorders·Lucas Bortolotto RizzoMoisés Evandro Bauer
Dec 31, 2014·PloS One·Estefania FiallosLiliana Soroceanu
Aug 9, 2016·Annual Review of Virology·Gabriella Campadelli-FiumeAndrew D Yurochko
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Jan 22, 2005·The Journal of General Virology·Jan Eike Eickhoff, Matt Cotten
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·K C Chin, P Cresswell
Nov 24, 2004·The Journal of General Virology·Markus RahausManfred H Wolff
Apr 29, 2005·Journal of Virology·Victor DeFilippis, Klaus Früh
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Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·H ZhuT Shenk

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