The Human Endocrine Pancreas: New Insights on Replacement and Regeneration

Trends in Endocrinology and Metabolism : TEM
Juan Domínguez-BendalaRicardo L Pastori

Abstract

Islet transplantation is an effective cell therapy for type 1 diabetes (T1D) but its clinical application is limited due to shortage of donors. After a decade-long period of exploration of potential alternative cell sources, the field has only recently zeroed in on two of them as the most likely to replace islets. These are pluripotent stem cells (PSCs) (through directed differentiation) and pancreatic non-endocrine cells (through directed differentiation or reprogramming). Here we review progress in both areas, including the initiation of Phase I/II clinical trials using human embryonic stem cell (hESc)-derived progenitors, advances in hESc differentiation in vitro, novel insights on the developmental plasticity of the pancreas, and groundbreaking new approaches to induce β cell conversion from the non-endocrine compartment without genetic manipulation.

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Citations

Aug 18, 2016·Development, Growth & Differentiation·Inchul Lee
Aug 20, 2016·Therapeutic Advances in Endocrinology and Metabolism·Elisa CorritorePhilippe A Lysy
Nov 14, 2017·Expert Opinion on Biological Therapy·Shengli Dong, Hongju Wu
May 20, 2021·Trends in Endocrinology and Metabolism : TEM·Juan Domínguez-BendalaRicardo Luis Pastori

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