PMID: 6397136Jan 1, 1984Paper

The human faecal flora and Crohn's disease

Antonie van Leeuwenhoek
J P Van de Merwe

Abstract

The aetiology of Crohn's disease (CD), a chronic inflammatory disease of the intestines, is not known but a genetic predisposition to CD has been well demonstrated. Studies on the isolation of bacteria from tissues and the faecal flora from CD patients are reviewed and their results compared with those from our laboratory. Serum antibodies against a variety of bacteria have been described but none has been found to be specific for CD. In our laboratory, higher numbers of coccoid anaerobes have been found in the faecal flora of CD patients. The use of agglutination reactions with four coccoid anaerobes as a diagnostic aid for CD is reviewed. No evidence has been found, however, for a primary role of the agglutinating antibodies in the pathogenesis of CD. On the other hand, one of the coccoid strains has been found to have several characteristics suggesting a role in CD, such as activation of the alternative pathway of complement, the failure of opsonization by specific IgG antibody and the binding of (non-specific) IgG onto the bacteria by the Fc portion. The composition of the faecal flora has been found to depend on genetic characteristics of the host. It is suggested that the genetic predisposition to CD is based on the genet...Continue Reading

References

Dec 1, 1978·Gut·M R KeighleyJ Alexander-Williams
Jan 1, 1975·Antonie van Leeuwenhoek·F Wensinck
Aug 1, 1985·European Journal of Immunology·J P Van de Merwe, J H Stegeman
Jul 1, 1971·Gut·A P Aluwihare
Jan 1, 1981·Scandinavian Journal of Gastroenterology·D DanielssonG Järnerot
Jan 1, 1981·Scandinavian Journal of Gastroenterology·A Krook
Mar 1, 1983·Scandinavian Journal of Gastroenterology·I Mattsby-BaltzerL Nilsson
Jun 1, 1983·Antonie van Leeuwenhoek·J G Ruseler-van Embden, H C Both-Patoir
Sep 1, 1983·Scandinavian Journal of Gastroenterology·M TvedeS N Rasmussen
Mar 1, 1983·Scandinavian Journal of Gastroenterology·I O AuerH Schmidt
Apr 1, 1984·Journal of Medical Microbiology·B HowellsJ Rhodes
Aug 19, 1983·Deutsche medizinische Wochenschrift·I O AuerS Schuster
Aug 1, 1981·The Journal of Hygiene·F WensinckA M Schröder
Aug 1, 1981·The Journal of Hygiene·F Wensinck, J P Van de Merwe
Nov 7, 1959·Lancet·B N BROOKE

❮ Previous
Next ❯

Citations

Nov 1, 1988·Scandinavian Journal of Gastroenterology·J P Van de MerweM P Hazenberg
May 1, 1993·Archives of Disease in Childhood·T T MacDonald
Mar 1, 1994·Baillière's Clinical Gastroenterology·T T MacDonald, S H Murch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.