PMID: 11309775Apr 20, 2001Paper

The human false-negative rate of rescreening Pap tests. Measured in a two-arm prospective clinical trial

Cancer
A A RenshawD C Wilbur

Abstract

Routine quality control rescreening often is used to calculate the false-negative rate (FNR) of gynecologic cytology. Theoretic analysis suggests that this is not appropriate, due to the high FNR of rescreening and the inability to actually measure it. The authors sought to determine the FNR of manual rescreening in a large, prospective, two-arm clinical trial using an analytic instrument in the evaluation. The results of the Autopap System Clinical Trial, encompassing 25,124 analyzed slides, were reviewed. The false-negative and false-positive rates at various thresholds were determined for routine primary screening, routine rescreening, Autopap primary screening, and Autopap rescreening by using a simple, standard methodology. The FNR of routine manual rescreening at the level of atypical squamous cells of undetermined significance (ASCUS) was 73%, more than 3 times the FNR of primary screening; 11 cases were detected. The FNR of Autopap rescreening was 34%; 80 cases were detected. Routine manual rescreening decreased the laboratory FNR by less than 1%; Autopap rescreening reduced the overall laboratory FNR by 5.7%. At the same time, the false-positive rate for Autopap screening was significantly less than that of routine man...Continue Reading

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Citations

Nov 14, 2000·Diagnostic Cytopathology·A A Renshaw
Sep 5, 2002·Cancer·Andrew A Renshaw
Feb 13, 2003·The American Journal of Nursing·Kim K Choma
Feb 24, 2005·Clinical Obstetrics and Gynecology·Jennifer RussellChristopher M Zahn
Apr 9, 2009·Clinical Nuclear Medicine·Kambiz RahbarLars Stegger
Oct 20, 2006·American Journal of Clinical Pathology·Andrew A Renshaw, Edwin W Gould
Oct 29, 2011·Archives of Pathology & Laboratory Medicine·Andrew A Renshaw
Dec 20, 2011·American Journal of Clinical Pathology·Heather S CurrensStephen S Raab
Nov 20, 2012·American Journal of Clinical Pathology·Mark H Stoler
Mar 18, 2009·American Journal of Clinical Pathology·Andrew A Renshaw
Dec 6, 2006·American Journal of Clinical Pathology·Andrew A Renshaw, Edwin W Gould
Jul 2, 2002·American Journal of Clinical Pathology·Andrew A RenshawMary L Young
Jun 24, 2004·Cancer·Andrew A RenshawE Blair Holladay
Jul 21, 2009·Cancer·Andrew A Renshaw
Apr 30, 2008·Cancer·Andrew A Renshaw
Sep 17, 2013·Cancer Cytopathology·Andrew A Renshaw, George G Birdsong
Dec 3, 2014·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Tegan EmersonPeter Kuhn
Jun 18, 2002·American Journal of Obstetrics and Gynecology·Juan C FelixStewart A Lonky
Apr 15, 2005·Cancer·Andrew A Renshaw
Jul 5, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Bruce K WobeserAndrew L Allen
Jun 16, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·A H G TobiasC M Carneiro
Oct 15, 2010·Diagnostic Cytopathology·Andrew A Renshaw, Tarik M Elsheikh
Nov 4, 2017·The Analyst·Marcus T Cicerone, Charles H Camp
Apr 30, 2005·Archives of Pathology & Laboratory Medicine·Andrew A RenshawUNKNOWN Cytopathology Resource Committee, College of American Pathologists
Oct 22, 2003·Archives of Pathology & Laboratory Medicine·Andrew A RenshawUNKNOWN College of American Pathologists Comparison Program in Cervicovaginal Cytology
Aug 13, 2002·Archives of Pathology & Laboratory Medicine·Andrew A RenshawMary L Young
May 11, 2006·Archives of Pathology & Laboratory Medicine·Andrew A Renshaw

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