The human fetal retinal nerve fiber layer and optic nerve head: a DiI and DiA tracing study

Visual Neuroscience
T Fitzgibbon

Abstract

The organization of the primate nerve fiber layer and optic nerve head with respect to the positioning of central and peripheral axons remains controversial. Data were obtained from 32 human fetal retinae aged between 15 and 21 weeks of gestation. Crystals of the carbocyanine dyes, DiI or DiA, and fluorescence microscopy were used to identify axonal populations from peripheral retinal ganglion cells. Peripheral ganglion cell axons were scattered throughout the vitreal-scleral depth of the nerve fiber layer. Such a scattered distribution was maintained as the fibers passed through the optic nerve head and along the optic nerve. There was a rough topographic representation within the optic nerve head according to retinal quadrant such that both peripheral and central fibers were mixed within a wedge extending from the periphery to the center of the nerve. There was no indication that the fibers were reorganized in any way as they passed through the optic disc and into the nerve. The present results suggest that any degree of order present within the fiber layer and optic nerve is not an active process but a passive consequence of combining the fascicles of the retinal nerve fiber layer. Optic axons are not instructed to establish...Continue Reading

References

Apr 26, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J E Cook, T J Horder
Jun 1, 1979·Archives of Ophthalmology·R L Radius, D R Anderson
Dec 13, 1979·Nature·J C HortonD H Hubel
Sep 8, 1992·The Journal of Comparative Neurology·T FitzGibbon, B E Reese
Jul 1, 1991·The Journal of Comparative Neurology·M M La VailP Rakic
Sep 1, 1989·Trends in Neurosciences·M G Honig, R I Hume
Jan 1, 1989·Visual Neuroscience·T Fitzgibbon, W Burke
Sep 15, 1986·The Journal of Comparative Neurology·J Naito
Jan 1, 1988·Progress in Neurobiology·J M Provis, P L Penfold
Jan 1, 1988·Annual Review of Neuroscience·S B Udin, J W Fawcett
May 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J H Sandell, R H Masland
May 8, 1987·The Journal of Comparative Neurology·J M Provis
Nov 8, 1987·The Journal of Comparative Neurology·R W Guillery, C Walsh
Apr 1, 1986·The Journal of Comparative Neurology·R W WilliamsL M Chalupa
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R W Williams, P Rakic
Jan 22, 1986·The Journal of Comparative Neurology·G M Horsburgh, A J Sefton
Aug 1, 1985·The Journal of Comparative Neurology·J M ProvisP Russell
Dec 1, 1972·The Journal of Comparative Neurology·S Goldberg, A J Coulombre
Nov 1, 1966·American Journal of Ophthalmology·F Vrabec
Mar 1, 1973·Developmental Biology·A W Spira, M J Hollenberg
Sep 1, 1980·Archives of Ophthalmology·D S Minckler
Jan 1, 1983·Progress in Brain Research·G Rager
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S ThanosU Rutishauser
Jan 1, 1983·Investigative Ophthalmology & Visual Science·T E Ogden
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·N Bodick, C Levinthal
May 1, 1982·Archives of Ophthalmology·H A Quigley, E M Addicks
Apr 10, 1982·The Journal of Comparative Neurology·S M Bunt
May 1, 1981·Developmental Biology·S Krayanek, S Goldberg
Jan 1, 1980·The Journal of Comparative Neurology·J Silver, R L Sidman
Feb 1, 1995·Trends in Neurosciences·R V Stirling, S A Dunlop
Nov 8, 1994·The Journal of Comparative Neurology·B E ReeseD R Hocking
Jun 1, 1994·The Journal of Comparative Neurology·S O Chan, R W Guillery
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Meissirel, L M Chalupa
Mar 22, 1994·The Journal of Comparative Neurology·B E ReeseJ D Peduzzi

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Citations

Oct 3, 2000·Ophthalmology·D F Garway-HeathR A Hitchings
Apr 11, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Gang HuangStephen A Burns
Apr 21, 2011·The Journal of Clinical Investigation·Yoko FukushimaAkiyoshi Uemura
Jun 4, 2013·Archivos de la Sociedad Española de Oftalmología·N GüerriL E Pablo
Sep 27, 2003·Acta Ophthalmologica Scandinavica·Lars Frisén, Kristina Malmgren
May 20, 2003·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Vikas GulatiRohit Saxena
Nov 23, 2011·Acta Ophthalmologica·Isabel Fuertes-LazaroLuis E Pablo
Jan 27, 1998·Experimental Eye Research·T FitzGibbon, Z Nestorovski
Apr 20, 2016·Frontiers in Neurology·Paul Rutkowski, Christian Albrecht May
Feb 24, 2001·Clinical & Experimental Ophthalmology·N WalshT FitzGibbon
Jan 31, 2017·Clinical & Experimental Ophthalmology·Thomas FitzGibbon
Nov 19, 2019·Vision·Christian Albrecht May, Paul Rutkowski
May 1, 2021·International Journal of Molecular Sciences·Hanhan Liu, Verena Prokosch

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