The human FXY gene is located within Xp22.3: implications for evolution of the mammalian X chromosome

Human Molecular Genetics
J PerryA Ashworth

Abstract

It has been proposed that the pseudoautosomal region of mammals has evolved by sequential addition of autosomal material onto the X and Y chromosomes followed by movement of the pseudoautosomal boundary to create X-unique regions. We have previously described a gene, Fxy , that spans the pseudoautosomal boundary in mice such that the first three exons of the gene are located on the X chromosome, but the remainder of the gene is located on both X and Y chromosomes. Therefore, this gene might be in a state of transition between pseudoautosomal and X-unique locations. In support of this theory we show here that the human FXY gene is located in Xp22.3 in humans, proximal to the pseudoautosomal boundary.

Citations

Dec 13, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Gaiping WenMatthias Platzer
Nov 8, 2003·Gene·Dmitry A Filatov, Dave T Gerrard
Nov 2, 2002·Molecular Biology and Evolution·Josette-Renée LandryDixie L Mager
Jan 21, 2016·Molecular Genetics & Genomic Medicine·Bijun LiYi Zou
Mar 25, 2008·Human Mutation·Bianca FontanellaGermana Meroni
Oct 6, 1999·Current Biology : CB·J Perry, A Ashworth
Aug 27, 1998·American Journal of Human Genetics·K GaudenzM Muenke
Jul 12, 2007·PloS One·Clara S M Tang, Richard J Epstein
Dec 8, 1998·American Journal of Medical Genetics·J K BrooksJ M Orenstein
Nov 3, 2001·Genome Research·J PerryA Ashworth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.