The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals

Genomics
E SuzukiK Walsh

Abstract

GATA factors constitute a family of transcriptional regulatory proteins expressed with distinct developmental and tissue-specific profiles and thought to regulate cell-restricted programs of gene expression. Here we describe the molecular cloning, chromosomal location, and transcription of the human GATA-6 gene. The GATA-6 cDNA encodes a predicted 449-amino-acid protein, which is highly conserved among vertebrates, and includes the two adjacent zinc-finger/basic domains characteristic of the GATA factor family. GATA-6 maps to human chromosome 18q11.1-q11.2 by fluorescence in situ hybridization. The gene is transcribed in a pattern overlapping that of GATA-4. Transcripts for both of these genes are prominent in heart, pancreas, and ovary, but only GATA-6 mRNA is found in lung and liver. GATA-6 transcripts are also detected in cultures of human and rat vascular smooth muscle cells (VSMCs). In VSMCs, GATA-6 transcripts are down- regulated when quiescent cultures are stimulated to proliferate in response to mitogen activation. These data demonstrate that GATA-6 is subject to both tissue-specific and mitogen-responsive regulatory signals. GATA-6 is a prime candidate for a gene that might regulate the differentiative state of VSMCs.

Citations

May 3, 2000·The EMBO Journal·S MorinM Nemer
Mar 31, 2006·Human Reproduction·Said AssouSamir Hamamah
Dec 2, 1999·Genes & Development·J F ReiterD Y Stainier
Dec 1, 2005·Development, Growth & Differentiation·Masatomo MaedaAyako Ohashi-Kobayashi
Jul 1, 2004·Molecular and Cellular Biology·Markella PonticosGeorge Bou-Gharios
Jan 5, 2008·Molecular Endocrinology·Robert S VigerMarkku Heikinheimo
Jul 19, 2014·International Journal of Molecular Sciences·Chunyu LiBo Yan
Mar 13, 2002·The Journal of Cell Biology·Hiromichi WadaShigetake Sasayama
Jul 4, 2012·European Journal of Medical Genetics·Yi-Qing YangXu Liu
Jan 8, 2008·Biochimica Et Biophysica Acta·Angela Ghatnekar, Maria Trojanowska
Feb 18, 2011·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Nicola FranchiEster Piccinni
Feb 22, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Abigale G Lade, Satdarshan P S Monga
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ruei-Ming ChenChih-Wei Chou
Aug 2, 2008·Biochemical and Biophysical Research Communications·Hiromichi WadaKoji Hasegawa
Sep 10, 2005·Brain Research. Developmental Brain Research·Deepak Kamnasaran, Abhijit Guha
Nov 19, 2005·Biochemical and Biophysical Research Communications·Shervin ShirvaniMichael T Chin
Apr 16, 2013·The American Journal of Pathology·Angela GhatnekarMaria Trojanowska
Jan 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Palmira D'AmbrosioAntonietta Spagnuolo
Mar 16, 2005·Molecular and Cellular Endocrinology·Sanne KiiveriMarkku Heikinheimo
Jun 29, 2013·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Li LiDe-pei Liu
Jun 5, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Herbert M van WeringStephen D Krasinski
Jan 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joyce K DivineTheodore C Simon
Feb 28, 2014·Journal of the American Heart Association·Yasmine F IbrahimYuichiro J Suzuki
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Mitsuru AbeToru Kita

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