The human hair follicle: a reservoir of CD40+ B7-deficient Langerhans cells that repopulate epidermis after UVB exposure

The Journal of Investigative Dermatology
A C GilliamK D Cooper

Abstract

The ability of skin to maintain its protective structural and functional integrity depends on both resident and circulating cells. Until now, it was thought that dendritic antigen presenting cells of epidermis (Langerhans cells) were replaced by circulating bone marrow derived precursors. Here we show by immunostaining studies of timed biopsies taken from human skin after ultraviolet exposure, that hair follicle is a critical reservoir of Langerhans cells that repopulate epidermis depleted of Langerhans cells by a single four minimal erythema dose of ultraviolet B. Immunostaining with antibodies to thymidine dimers showed that ultraviolet B only penetrated the superficial hair follicle opening, whereas deeper follicle was relatively protected. Langerhans cells migrating from hair follicle into epidermis 72 h after ultraviolet exposure have a partial deficiency of molecules important to T cell costimulation. We used four color flow cytometry to show that Langerhans cells isolated from epidermis 72 h after ultraviolet B can upregulate CD40 but not B7-1 or B7-2 expression in culture, suggesting a different phenotype of hair follicle Langerhans cells. Therefore, the hair follicle is a specialized immune compartment of the skin that...Continue Reading

References

Jul 21, 1977·Nature·G RowdenA K Sullivan
Aug 1, 1976·Cellular Immunology·I Silberberg-SinakinV Berezowsky
Mar 1, 1985·The Journal of Experimental Medicine·G Schuler, R M Steinman
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C D GimmiL M Nadler
Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
Jan 1, 1996·Annual Review of Immunology·T M FoyR J Noelle

❮ Previous
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Citations

Sep 1, 1999·The British Journal of Dermatology·E HodakM David
Aug 12, 1999·The New England Journal of Medicine·R Paus, G Cotsarelis
Aug 3, 1999·The Journal of Experimental Medicine·U V WesleyA N Houghton
Apr 9, 2009·Cancer Research·Fei DuanAlan N Houghton
Apr 15, 2006·The Journal of Clinical Investigation·José A Guevara-PatiñoAlan N Houghton
Jan 6, 2006·The Journal of Clinical Investigation·George Cotsarelis
Jan 30, 2009·Blood·Miriam Merad, Markus G Manz
Oct 30, 2010·Trends in Immunology·Laurent Chorro, Frédéric Geissmann
Jan 16, 2010·Forensic Science International : Synergy·Joey Gareri, Gideon Koren
Feb 22, 2013·The Journal of Investigative Dermatology·Renato B BaleeiroPeter Walden
Jun 17, 2006·The Journal of Investigative Dermatology·George Cotsarelis
Nov 10, 2004·International Journal of Dermatology·Simin MeymandiArsalan Kharazmi
Apr 30, 2013·Immunology·Matthew CollinMuzlifah Haniffa
Aug 23, 2011·Microbial Biotechnology·Steffi Hansen, Claus-Michael Lehr
Nov 15, 2014·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·D Wilsmann-Theis, T Bieber
Dec 24, 2014·PLoS Biology·Donatello CastellanaMirna Perez-Moreno
Nov 22, 2002·Journal of Dermatological Science·Kayo TairaTatsurou Tanaka
May 16, 2000·The British Journal of Dermatology·T ChristophR Paus
Jul 20, 1999·Dermatologic Clinics·C Jaworsky, A C Gilliam
Oct 11, 2017·Viruses·Samuel AlizonIgnacio G Bravo
Jun 21, 2006·Medical Microbiology and Immunology·Uwe Ritter, Anke Osterloh
Nov 26, 2008·Nature Reviews. Immunology·Miriam MeradMatthew Collin
Feb 5, 2019·Current Drug Delivery·Heather A E BensonMichael S Roberts
Jan 17, 2014·Expert Review of Vaccines·Steffi Hansen, Claus-Michael Lehr
May 10, 2003·Blood·Tadashi KumamotoAkira Takashima
Jan 12, 2001·Physiological Reviews·K S Stenn, R Paus
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan ZhangAnita C Gilliam
Sep 13, 2008·Clinical Science·Heraldo P SouzaRita C Tostes
Jun 24, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia HemmerlingRalf G Meyer
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcel B M TeunissenJan D Bos
Feb 25, 2017·Pflügers Archiv : European journal of physiology·Diana A YanezOscar R Colegio
Jul 17, 1998·The Journal of Investigative Dermatology·R PausU Hofmann
Sep 3, 2002·Survey of Ophthalmology·Murray A Johnstone, Daniel M Albert
Sep 24, 2002·Journal of Cell Science·Majlinda LakoColin A B Jahoda
Apr 15, 2004·Medical Hypotheses·Shi Chunmeng, Cheng Tianmin
Sep 7, 2021·Angewandte Chemie·Neha TiwariMarcelo Calderón

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