The human hippocampus is not sexually-dimorphic: Meta-analysis of structural MRI volumes

NeuroImage
Anh TanLise Eliot

Abstract

Hippocampal atrophy is found in many psychiatric disorders that are more prevalent in women. Sex differences in memory and spatial skills further suggest that males and females differ in hippocampal structure and function. We conducted the first meta-analysis of male-female difference in hippocampal volume (HCV) based on published MRI studies of healthy participants of all ages, to test whether the structure is reliably sexually dimorphic. Using four search strategies, we collected 68 matched samples of males' and females' uncorrected HCVs (in 4418 total participants), and 36 samples of male and female HCVs (2183 participants) that were corrected for individual differences in total brain volume (TBV) or intracranial volume (ICV). Pooled effect sizes were calculated using a random-effects model for left, right, and bilateral uncorrected HCVs and for left and right HCVs corrected for TBV or ICV. We found that uncorrected HCV was reliably larger in males, with Hedges' g values of 0.545 for left hippocampus, 0.526 for right hippocampus, and 0.557 for bilateral hippocampus. Meta-regression revealed no effect of age on the sex difference in left, right, or bilateral HCV. In the subset of studies that reported it, both TBV (g=1.085) a...Continue Reading

References

Aug 1, 1992·Trends in Neurosciences·D F SherryS J Gaulin
Jan 1, 1991·Psychoneuroendocrinology·C L Williams, W H Meck
May 1, 1995·The American Journal of Psychiatry·M FlaumN C Andreasen
Jul 1, 1994·Cerebral Cortex·P A FilipekV S Caviness
Apr 10, 1999·Archives of General Psychiatry·I AgartzD W Hommer
Jan 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·K RaziL E DeLisi
Mar 14, 1997·Psychiatry Research·N LangeJ L Rapoport
Sep 15, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·S DurstonH van Engeland
Feb 13, 2002·American Journal of Medical Genetics·Anil J PatwardhanAllan L Reiss
Jun 22, 2002·Brain : a Journal of Neurology·Chiara NosartiRobin M Murray
Aug 17, 2002·Cerebral Cortex·Ruben C GurRaquel E Gur
Apr 23, 2003·Perceptual and Motor Skills·Deborah A Yurgelun-ToddChristina B Cintron
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Jul 30, 2003·Neurobiology of Aging·J L EberlingW J Jagust
Mar 31, 2004·NeuroImage·Katherine L NarrRobert M Bilder
May 29, 2004·Neurobiology of Aging·David J A CallenCheryl L Grady
Jun 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Adrian J LloydJohn T O'Brien
Jun 24, 2004·Neurobiology of Aging·Henrike WolfHermann-Josef Gertz
Jul 9, 2004·Cerebral Cortex·Michio SuzukiMasayoshi Kurachi
Jul 21, 2004·Molecular Psychiatry·T den HeijerM M B Breteler
Aug 26, 2004·Journal of the International Neuropsychological Society : JINS·Otto PedrazaRobin Gilmore
Sep 17, 2004·Cerebral Cortex·Denise HeadRandy L Buckner
Oct 30, 2004·The American Journal of Psychiatry·Poul Videbech, Barbara Ravnkilde
Apr 12, 2005·Biological Psychiatry·Alexander NeumeisterWayne C Drevets
May 11, 2005·Journal of Neurobiology·Bradley M Cooke, Catherine S Woolley
Oct 4, 2005·Biological Psychiatry·Larry A Tupler, Michael D De Bellis
Feb 18, 2006·Dementia and Geriatric Cognitive Disorders·P S SachdevA F Jorm

❮ Previous
Next ❯

Citations

Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Margaret M McCarthy
Oct 1, 2016·Acta Radiologica·Karin PerssonKnut Engedal
Sep 14, 2017·Alzheimer's Research & Therapy·Jessica Z K CaldwellUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 7, 2018·Human Brain Mapping·Arash Aghamohammadi-SereshkiNikolai V Malykhin
Jan 10, 2019·Infant Mental Health Journal·Jorge Luis GarcíaAnna L Ziff
Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Donna L Maney
Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Daphna Joel, Anne Fausto-Sterling
Sep 12, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Enrica CavedoUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Jun 21, 2019·Applied Psychophysiology and Biofeedback·Maria PallayovaDiana Tokarova
Nov 22, 2016·Journal of Neuroscience Research·Aarthi R GobinathLiisa A M Galea
May 18, 2018·Cerebral Cortex·Stuart J RitchieIan J Deary
Jun 23, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonia N KaczkurkinTheodore D Satterthwaite
Mar 13, 2019·Plastic and Reconstructive Surgery. Global Open·Garyfalia LekakisPeter W Hellings
Apr 23, 2020·Frontiers in Neuroscience·Marek KijonkaBarbara Bobek-Billewicz
Feb 23, 2019·Frontiers in Neuroinformatics·David N KennedyMatt Travers
Oct 6, 2020·The Journal of Comparative Neurology·Sashrika PillayPaul R Manger
Oct 13, 2020·Human Brain Mapping·Lara M WierengaChristian K Tamnes
Dec 22, 2020·Frontiers in Human Neuroscience·Shu Hua MuLi Hai Tan
Jan 1, 2021·PLoS Biology·Katherine L BryantRogier B Mars
Sep 2, 2019·Trends in Neurosciences·Natalie C Tronson, Ashley A Keiser
Aug 12, 2020·Progress in Neurobiology·Giulia TorrominoElvira De Leonibus
Nov 15, 2020·Scientific Reports·Jilu P MoleClaudia Metzler-Baddeley
Jan 11, 2021·Journal of Affective Disorders·Sneha ChenjiFrank P MacMaster
Aug 15, 2019·Entropy·Elizabeth ShumbayawondaAlberto Fernández
Feb 25, 2018·Computers in Biology and Medicine·Vanderson DillMárcio Sarroglia Pinho
Dec 31, 2017·Neuroscience and Biobehavioral Reviews·Elena CholerisKaryn M Frick
May 6, 2021·Human Brain Mapping·Lauren E SalminenPaul M Thompson
May 8, 2021·Psychoneuroendocrinology·Paula Duarte-Guterman On Behalf Of The Alzheimer's Disease Neuroimaging Initiative
Jul 17, 2021·Human Brain Mapping·Camille Michèle WilliamsFranck Ramus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.