PMID: 9174161May 1, 1997Paper

The human homeodomain protein OTX2 binds to the human tenascin-C promoter and trans-represses its activity in transfected cells

DNA and Cell Biology
R GherziL Zardi

Abstract

Homeodomain-containing proteins mediate many transcriptional processes in eukaryotes during development. Recently, mammalian homeodomain proteins involved in the anterior head formation have been discovered, but their effect on gene transcription has never been investigated. Here we report on the ability of the human homeodomain protein OTX2 to bind with high affinity to a target sequence present in the promoter of the gene encoding the human extracellular matrix protein tenascin-C and to repress its transcriptional activity in transiently transfected cells.

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Citations

Apr 27, 1999·Brain Research. Molecular Brain Research·K T Nguyen Ba-CharvetP Godement
Dec 5, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·P L Jones, F S Jones
Feb 8, 2006·Journal of Neuropathology and Experimental Neurology·Talitha de HaasMarcel Kool
Apr 29, 2015·Glia·Andreas Faissner, Jacqueline Reinhard
Jan 8, 2008·Biochimica Et Biophysica Acta·Angela Ghatnekar, Maria Trojanowska
Feb 5, 2008·Clinical Genetics·J T Wigle, D D Eisenstat
Feb 8, 2011·Clinical Genetics·C Sergi, D Kamnasaran
Nov 6, 2009·Journal of Cellular Physiology·Gianfranco BellipanniEric S Weinberg
Mar 21, 2015·Cell Adhesion & Migration·Francesca ChiovaroMatthias Chiquet
Dec 9, 2014·Cell Adhesion & Migration·Sean P Giblin, Kim S Midwood
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Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shuichi WadaHidetoshi Saiga
Nov 12, 2016·Molecular and Cellular Neurosciences·Andreas FaissnerUrsula Theocharidis
Feb 1, 2007·The Journal of Biological Chemistry·Alexander von HolstAndreas Faissner
Nov 23, 2016·Journal of Cell Science·Kim S MidwoodGertraud Orend

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