PMID: 8970948Dec 1, 1996Paper

The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses

Journal of Virology
Stephan Bour, K Strebel

Abstract

We have recently shown that the envelope glycoprotein of the ROD10 isolate of human immunodeficiency virus type 2 (HIV-2) has the ability to positively regulate HIV-2 viral particle release. The activity provided by the ROD10 Env was remarkably similar to that of the HIV-1 Vpu protein, thus raising the possibility that the two proteins act in a related fashion. We now show that the ROD10 Env can functionally replace Vpu to enhance the rate of HIV-1 particle release. When provided in trans, both Vpu and the ROD10 Env restored wild-type levels of particle release in a Vpu-deficient mutant of the NL4-3 molecular clone with indistinguishable efficiencies. This effect was independent of the presence of the HIV-1 envelope protein. The ROD10 Env also enhanced HIV-1 particle release in the context of HIV-2 chimeric viruses containing the HIV-1 gag-pol, indicating a lack of need for additional HIV-1 products in this process. In addition, we show for the first time that HIV-1 Vpu, as well as ROD10 Env, has the ability to enhance simian immunodeficiency virus (SIV) particle release. The effects of Vpu and ROD10 Env on SIV particle release were indistinguishable and were observed in the context of full-length SIVmac239 and simian-human imm...Continue Reading

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Citations

May 21, 2010·PLoS Pathogens·Janet L DouglasKlaus Früh
Jan 12, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Björn D KuhlChen Liang
Jul 20, 2012·Molecular Biology International·Jason HammondsPaul Spearman
May 20, 2015·Nature Immunology·Viviana SimonNathaniel R Landau
Nov 24, 1999·The Journal of Biological Chemistry·S BourK Strebel
Feb 16, 2002·Protein Science : a Publication of the Protein Society·Che MaStanley J Opella
Sep 16, 2003·FEBS Letters·Maria Eugenia Gonzalez, Luis Carrasco
Sep 18, 2009·BMC Medicine·Klaus StrebelKuan-Teh Jeang
Nov 28, 2008·Journal of Virology·Nolwenn JouvenetPaul D Bieniasz
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vasundhara VarthakaviPaul Spearman
Dec 21, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Amy Andrew, Klaus Strebel
Apr 5, 2016·Immunity, Inflammation and Disease·Wadie D Mahauad-Fernandez, Chioma M Okeoma
Oct 30, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ravindra K GuptaGreg J Towers
Aug 8, 2015·Viruses·María Eugenia González
May 10, 2016·The Journal of Clinical Investigation·Kenta MatsudaVanessa M Hirsch
Nov 1, 2017·Viruses·Tanja SeisslerJean-Christophe Paillart
Sep 18, 2007·The Journal of General Virology·Kathryn H Richards, Paul R Clapham

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