The Human Left Atrial Venous Circulation as a Vascular Route for Atrial Pharmacological Therapies: Effects of Ethanol Infusion

JACC. Clinical Electrophysiology
Miguel ValderrábanoAmish S Dave

Abstract

This study catalogued the human venous left atrium (LA) circulation system and the ablative effects of ethanol in different branches. Vascular routes to target the LA could have significant therapeutic potential. Beyond the vein of Marshall (VOM), the fluoroscopic LA venous anatomy has not been described. Patients undergoing ethanol infusion in the VOM as adjunctive therapy to atrial fibrillation (AF) catheter ablation were included in this study. Balloon occlusion venograms of the VOM and other LA veins were obtained in 218 patients. Sequentially from the coronary sinus (CS) ostium, LA veins included: 1) proximal septal vein draining the inferior septum; 2) inferior LA vein in the annular inferior LA; 3) VOM; 4) LA appendage vein; and 4) anterior LA vein. Additionally, venous sinuses not connected to the CS included roof veins and posterior wall veins, which drained into the right and left atria, respectively. Venous connections between LA veins through capillaries and with pulmonary veins were abundant. Extracardiac collateral vessels were present in 38 patients (17.4%). Ethanol infusion in LA veins led to tissue ablation in their corresponding regions. The atrial venous anatomy is amenable to selective cannulation. Consisten...Continue Reading

Citations

Feb 26, 2019·Journal of Cardiovascular Electrophysiology·Masateru TakigawaNicolas Derval
May 31, 2019·Journal of Cardiovascular Electrophysiology·Miguel Valderrábano
Jan 16, 2020·Circulation. Arrhythmia and Electrophysiology·Masateru TakigawaPierre Jaïs
Nov 19, 2020·European Heart Journal. Case Reports·Severine PhilibertGabriel Laurent
Mar 31, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Miguel Valderrábano
Apr 17, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Miguel ValderrábanoKaoru Okishige
May 10, 2021·Indian Pacing and Electrophysiology Journal·Kohki NakamuraShigeto Naito
May 15, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Liliana TavaresMiguel Valderrábano
Jun 10, 2021·Methodist DeBakey Cardiovascular Journal·Adi Lador, Miguel Valderrábano
Jul 20, 2021·Circulation. Arrhythmia and Electrophysiology·Tsukasa KamakuraThomas Pambrun
Aug 27, 2021·HeartRhythm Case Reports·Wataru SasakiShigeto Naito
Oct 20, 2021·Journal of Cardiovascular Electrophysiology·Yoshikazu SatoTetsuo Sasano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

© 2022 Meta ULC. All rights reserved