The human lung and Aspergillus: You are what you breathe in?

Medical Mycology
Malcolm RichardsonRaquel Sabino

Abstract

The diversity of fungal species comprising the lung mycobiome is a reflection of exposure to environmental and endogenous filamentous fungi and yeasts. Most lung mycobiome studies have been culture-based. A few have utilized next generation sequencing (NGS). Despite the low number of published NGS studies, several themes emerge from the literature: (1) moulds and yeasts are present in the human respiratory tract, even during health; (2) the fungi present in the respiratory tract are highly variable between individuals; and (3) many diseases are accompanied by decreased diversity of fungi in the lungs. Even in patients with the same disease, different patients have been shown to harbor distinct fungal communities. Those fungal species present in any one individual may represent a patient's unique environmental exposure(s), either to species restricted to the indoor environment, for example, Penicillium, or species found in the outdoor environment such as Aspergillus, wood and vegetation colonizing fungi and plant pathogens. In addition to causing clinical fungal infections, the lung mycobiome may have inflammatory effects that can cause or worsen lung disease. Most respiratory diseases that have been studied, have been associate...Continue Reading

References

Aug 8, 2006·Journal of Clinical Microbiology·Luciana C PaulinoMartin J Blaser
Oct 17, 2006·The Annals of Otology, Rhinology & Laryngology. Supplement·Donald C LanzaDavid W Kennedy
Nov 6, 2007·Applied and Environmental Microbiology·M PitkärantaH Rintala
Jul 15, 2009·Clinical Microbiology Reviews·Taylor R T Dagenais, Nancy P Keller
Jan 15, 2010·PLoS Pathogens·Mahmoud A GhannoumPatrick M Gillevet
May 8, 2010·Journal of Environmental Monitoring : JEM·Manuela OliveiraIlda Abreu
Feb 7, 2012·Advances in Applied Microbiology·Helena RintalaMartin Täubel
Feb 11, 2012·Current Allergy and Asthma Reports·Andrew ForemanPeter-John Wormald
Jul 17, 2012·American Journal of Respiratory and Critical Care Medicine·Emily S CharlsonRonald G Collman
Feb 7, 2013·Critical Reviews in Microbiology·Anuradha ChowdharyJacques F Meis
Apr 17, 2013·Critical Reviews in Microbiology·Delphine MéheustJean-Pierre Gangneux
May 10, 2013·BMC Infectious Diseases·Sam BoasePeter-John Wormald
Aug 24, 2013·BioMed Research International·Sanjay H ChotirmallNoel G McElvaney
Nov 2, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Rajeev AuroraThomas Sanford
Feb 7, 2014·International Forum of Allergy & Rhinology·Edward John ClelandPeter-John Wormald
Aug 26, 2014·Lancet·Robert P DicksonGary B Huffnagle
Jan 21, 2015·American Journal of Respiratory and Critical Care Medicine·Lijia CuiElodie Ghedin
Sep 12, 2015·Mycologia·Mallory J Suhr, Heather E Hallen-Adams
Apr 20, 2016·Frontiers in Microbiology·Sarah K HiltonKeith A Crandall
Jul 9, 2017·Infectious Disease Clinics of North America·Luis Ostrosky-Zeichner, Mohanad Al-Obaidi
Jul 14, 2017·BMC Microbiology·Brandilyn A PetersJiyoung Ahn
Aug 15, 2017·The Science of the Total Environment·Kanistha CoombsTiina Reponen
Oct 6, 2017·Microbiome·Xinzhao TongPatrick K H Lee
Nov 11, 2017·The Journal of Allergy and Clinical Immunology·Marcin G FraczekPaul Bowyer
Jan 5, 2018·International Journal of Molecular Sciences·Luis MáizMiguel Ángel Martinez-García
Jan 27, 2018·Journal of Fungi·Elizabeth A WitherdenDavid L Moyes
Jun 9, 2018·The European Respiratory Journal·Micheál Mac AogáinSanjay H Chotirmall
Jun 13, 2018·The Science of the Total Environment·Estelle BaurèsArnaud Florentin

❮ Previous
Next ❯

Citations

Jan 10, 2019·Microorganisms·Malcolm Richardson, Riina Rautemaa-Richardson
Apr 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ping ZhuJin Chen
Jan 3, 2020·Mycopathologia·Pei Yee TiewSanjay H Chotirmall
Feb 29, 2020·Scientific Reports·Perrine SoretUNKNOWN Mucofong Investigation Group
Sep 13, 2020·Nature Reviews. Immunology·Harald Renz, Chrysanthi Skevaki
Jan 22, 2021·Environmental Science & Technology·Lynn E SecondoGediminas Mainelis
Jan 10, 2021·Microorganisms·Kenia C Sánchez EspinosaMaría Del Rocío Reyes-Montes
Nov 4, 2020·BMC Genomics·Alexander J CarrilloKatherine A Borkovich
Nov 6, 2020·Microorganisms·Esther Rubio-PortilloMaría Francisca Colom
Sep 15, 2020·The Journal of Allergy and Clinical Immunology·Louise-Eva VandenborghtLaurence Delhaes
Apr 4, 2021·International Journal of Environmental Research and Public Health·Maiko WatanabeYukiko Hara-Kudo
Jun 21, 2021·Ecotoxicology and Environmental Safety·Khairul Nizam Mohd IsaZailina Hashim
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Tavleen Kaur JaggiSanjay H Chotirmall
Aug 29, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Juergen PrattesUNKNOWN ECMM-CAPA Study Group

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleic acid amplification
amplicon sequencing
PCR
bronchoalveolar lavage

Software Mentioned

SourceTracker

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.