The Human Microcirculation: Regulation of Flow and Beyond

Circulation Research
David D GuttermanAndreas M Beyer

Abstract

The microcirculation is responsible for orchestrating adjustments in vascular tone to match local tissue perfusion with oxygen demand. Beyond this metabolic dilation, the microvasculature plays a critical role in modulating vascular tone by endothelial release of an unusually diverse family of compounds including nitric oxide, other reactive oxygen species, and arachidonic acid metabolites. Animal models have provided excellent insight into mechanisms of vasoregulation in health and disease. However, there are unique aspects of the human microcirculation that serve as the focus of this review. The concept is put forth that vasculoparenchymal communication is multimodal, with vascular release of nitric oxide eliciting dilation and preserving normal parenchymal function by inhibiting inflammation and proliferation. Likewise, in disease or stress, endothelial release of reactive oxygen species mediates both dilation and parenchymal inflammation leading to cellular dysfunction, thrombosis, and fibrosis. Some pathways responsible for this stress-induced shift in mediator of vasodilation are proposed. This paradigm may help explain why microvascular dysfunction is such a powerful predictor of cardiovascular events and help identify n...Continue Reading

References

Jan 1, 1991·Clinical and Experimental Pharmacology & Physiology·J A AngusA Broughton
Nov 17, 1988·The New England Journal of Medicine·J E BrushS E Epstein
Jun 1, 1988·The American Journal of Cardiology·R O Cannon, S E Epstein
Oct 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·C Ody, A F Junod
Dec 1, 1974·The Journal of Clinical Investigation·R A KlonerR B Jennings
Nov 1, 1995·Journal of the American College of Cardiology·T J AndersonA C Yeung
Apr 1, 1995·The American Journal of Physiology·M T Nelson, J M Quayle
Apr 1, 1995·Journal of the American College of Cardiology·W F PennyK L Peterson
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·F DupratE Honore
Jan 1, 1996·Pflügers Archiv : European journal of physiology·G J StephensB Robertson
May 31, 1996·The Journal of Biological Chemistry·S AddaM I Kotlikoff
Jul 1, 1996·The American Journal of Physiology·A CarlK M Sanders
Mar 1, 1997·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·W F JacksonN J Rusch
Nov 14, 1997·Physiological Reviews·J M QuayleN B Standen
Jun 18, 1999·British Journal of Pharmacology·B K Kemp, T M Cocks
Sep 20, 2000·Journal of Hypertension·M FürstenauM Gollasch
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K TerataD D Gutterman
Dec 20, 2000·The Journal of Clinical Investigation·T MatobaA Takeshita
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·M BrunoriM T Wilson
Mar 10, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·O PlatoshynJ X Yuan
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A HuangG Kaley
Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A W MillerG O Carrier
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·An HuangGabor Kaley
Jan 19, 2002·Biochemical and Biophysical Research Communications·Tetsuya MatobaAkira Takeshita
Aug 7, 2002·Circulation·Julian P J HalcoxArshed A Quyyumi
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Atsushi SatoDavid D Gutterman
Sep 13, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Atsushi KatohTsutomu Imaizumi
Sep 27, 2002·Current Eye Research·Arpenik AvakianPatricia Parsons-Wingerter
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Meetha MedhoraDavid R Harder
Dec 11, 2002·The Journal of Biological Chemistry·Malgorzata CzarnyJan E Schnitzer
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Shailesh S DeshpandeKaikobad Irani
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brian N FinckDaniel P Kelly
Feb 7, 2003·Journal of the American College of Cardiology·Masahiro MohriAkira Takeshita

❮ Previous
Next ❯

Citations

Jan 22, 2017·Schizophrenia Research·Hsiao-Lun KuNai-Fang Chi
Nov 16, 2017·American Journal of Hypertension·Andrew O KadlecDavid D Gutterman
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Andrew O Kadlec, David D Gutterman
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Karima Ait-AissaAndreas M Beyer
Nov 1, 2017·Critical Reviews in Clinical Laboratory Sciences·Rayan Khaddaj MallatAndrew P Braun
Aug 18, 2017·The Journal of Endocrinology·Rhonda D Prisby
Jun 23, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Kent A LemasterJefferson C Frisbee
Aug 25, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Shigeo Godo, Hiroaki Shimokawa
Aug 22, 2018·Canadian Journal of Physiology and Pharmacology·Dragan DjuricIvan Srejovic
Oct 28, 2016·Journal of Biomechanical Engineering·Samuel G Rayner, Ying Zheng
Jul 1, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Tyler CalwaySteven Roth
Sep 15, 2017·Journal of the American Society of Nephrology : JASN·Alfons J H M HoubenCoen D A Stehouwer
Feb 2, 2019·Physics in Medicine and Biology·Anthony J Deegan, Ruikang K Wang
Jul 19, 2019·Circulation Research·Kenneth M BorowEmerson C Perin
Nov 30, 2019·Alcoholism, Clinical and Experimental Research·Chueh-Lung HwangShane A Phillips
Oct 16, 2019·Journal of Cardiovascular Pharmacology·Kazuo Yamagata, Yukio Yamori
May 14, 2020·Advanced Biosystems·Maria Angélica Luque-GonzálezDavid Caballero
Sep 13, 2019·Annals of Intensive Care·Matthieu LegrandHafid Ait-Oufella
Sep 18, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Boran KatunaricJulie K Freed
Jun 2, 2018·Nature Reviews. Rheumatology·Romain BordyCéline Demougeot
Oct 17, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Raimund H M PreidlFalk Wehrhan
Jan 9, 2019·Frontiers in Cardiovascular Medicine·Elena BartoloniRoberto Gerli
Jun 7, 2019·Frontiers in Immunology·Patricia Ruiz-LimonUNKNOWN PRECISESADS Clinical Consortium and Flow Cytometry Study Group
Jun 4, 2017·Heart Failure Reviews·Paco E BravoSharmila Dorbala
Mar 18, 2017·Physiological Measurement·John M Karemaker
Apr 20, 2019·Frontiers in Cell and Developmental Biology·Benjamin SanchezDominique Sigaudo-Roussel
Apr 4, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Dawid S ChabowskiJulie K Freed
Oct 22, 2016·Clinical Hemorheology and Microcirculation·Maria das Graças Coelho de SouzaEliete Bouskela
May 10, 2017·Journal of Cardiovascular Pharmacology·Julie K Freed, David D Gutterman
Nov 28, 2017·Alcoholism, Clinical and Experimental Research·Jing-Tan BianShane A Phillips

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Circulation Journal : Official Journal of the Japanese Circulation Society
Yukihito HigashiYasuki Kihara
Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Matthew J Durand, David D Gutterman
© 2021 Meta ULC. All rights reserved