The human neostriatum shows compartmentalization of neuropeptide gene expression in dorsal and ventral regions: an in situ hybridization histochemical analysis

Neuroscience
Y L Hurd, M Herkenham

Abstract

Expression of neuropeptide messenger RNAs in striatal neurons was studied in post mortem human brain tissue by the use of in situ hybridization histochemistry. Clusters of cells expressing high levels of prodynorphin messenger RNA, and less strikingly, preprotachykinin messenger RNA, were prominent in the caudate nucleus and were present but less pronounced in the putamen. Proenkephalin and prosomatostatin messenger RNA-containing cells were more homogeneously distributed throughout the striatum, though the latter were much sparser. The four neuropeptide messenger RNA patterns in the nucleus accumbens were rather homogeneous compared with the dorsal striatum. Of these, prodynorphin messenger RNA showed a higher level of expression per cell in the nucleus accumbens relative to the dorsal striatum. The relationship of neuropeptide-containing cell clusters to the striosomal organization was characterized by looking at the register of these markers with patterns of low acetylcholinesterase activity and dense mu opiate receptor binding. In the caudate and putamen, clusters of cells expressing high levels of dynorphin and preprotachykinin messenger RNAs were clearly in register with the striosomes. The accumbens was defined by high p...Continue Reading

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A M Graybiel, C W Ragsdale
Jun 9, 1977·Nature·J A LordH W Kosterlitz
Mar 15, 1978·The Journal of Comparative Neurology·J E Krettek, J L Price
Nov 1, 1992·Brain Research. Molecular Brain Research·Y L Hurd, M Herkenham
Mar 1, 1992·Brain Research. Molecular Brain Research·Y L HurdC R Gerfen
Sep 11, 1991·The Journal of Comparative Neurology·C W Ragsdale, A M Graybiel
Mar 1, 1986·Neuroscience·J K MaiA C Cuello
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W S YoungM R Brann
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J E KrauseA D Hershey
Jan 1, 1989·Neuroscience·J Jiménez-Castellanos, A M Graybiel
Dec 15, 1989·The Journal of Comparative Neurology·B J Morris
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A M Graybiel, R Moratalla
Jan 1, 1986·Applied Neurophysiology·M Wiesendanger
Jul 22, 1988·The Journal of Comparative Neurology·S Fitzpatrick-McElligottF Baldino
Oct 11, 1988·European Journal of Pharmacology·G R HansonJ W Gibb
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·O CivelliE Herbert

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Citations

Jul 15, 1999·The Journal of Comparative Neurology·Y L HurdG Sedvall
Nov 12, 2013·Neuropeptides·Stjepana Kovac, Matthew C Walker
Oct 14, 2003·Experimental Neurology·Brian HenryJonathan M Brotchie
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·J B DaunaisL J Porrino
Mar 17, 2000·Brain Research. Brain Research Reviews·L Heimer
Apr 4, 1998·Brain Research. Molecular Brain Research·M OsterlundY L Hurd
Mar 27, 2012·Genes, Brain, and Behavior·T-K ClarkeF W Lohoff
Jul 23, 1999·Annals of the New York Academy of Sciences·S N Haber, N R McFarland
Sep 16, 1995·Lancet·G Sedvall, L Farde
May 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Katarina DrakenbergYasmin L Hurd
Sep 25, 1995·The Journal of Comparative Neurology·C BranaB Bloch
Jun 6, 2003·The European Journal of Neuroscience·P FagergrenY L Hurd
May 8, 2008·The Journal of Comparative Neurology·Kaoru TakahashiHiroshi Takahashi
Jan 28, 2006·The Journal of Comparative Neurology·Virgina M PickelKenneth Mackie
Apr 15, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gabor EgervariYasmin L Hurd
Jul 19, 2001·Annals of the New York Academy of Sciences·T S ShippenbergC A Heidbreder
Feb 23, 2000·Neuroscience·R Rodríguez-PuertasA Pazos

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