The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization.

Parasites & Vectors
Nicholas TendongforAchim Hoerauf

Abstract

Immunological mechanisms involved in the survival and development of human filarial species in the vertebrate host are poorly known due to the lack of suitable experimental models. In order to understand the role of cytokines in the survival and development of filarial larvae in the vertebrate host, we infected different strains of BALB/c mice deficient in a number of cytokine or cytokine receptor genes with Loa loa. The survival and development of larvae were monitored. BALB/c mice genetically deficient in IL-4R, IFN-γ, IFN-γ/IL-5, IL-5, and IL-4R/IL-5 cytokine or cytokine receptor genes were infected with a human strain of L. loa and necropsies were performed at different time intervals up to 70 days post infection to monitor the survival and development of L. loa larvae. The larvae were teased out of the skin, muscles, peritoneal and pleural cavities, heart and lung tissues. The length and width of the recovered larvae were measured to assess their growth. In mice deficient for IL-4R, IFN-γ, IFN-γ/IL-5, IL-5 and IL-4R/IL-5, the larvae survived up to 5, 20, 40, 50 and 70 days respectively. Worms recovered 70 days post infection in IL-4R/IL-5 DKO mice were young adults and measured 10.12 mm in length and 0.1 mm in width. Overa...Continue Reading

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Citations

Jul 18, 2015·PLoS Neglected Tropical Diseases·Hugo C TurnerMaría-Gloria Basáñez
Feb 9, 2017·Scandinavian Journal of Immunology·A Kwarteng, S T Ahuno
Jun 24, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolas PionnierJoseph D Turner
Mar 31, 2019·Nature Communications·Nicolas P PionnierJoseph D Turner
Aug 18, 2020·PLoS Neglected Tropical Diseases·Lontum B NdzeshangSamuel Wanji

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