Abstract
The initial event in the life cycle of a virus is its interaction with specific receptors present on the surface of a cell. Understanding these interactions is important to our understanding of viral tropism and tissue specific pathology associated with viral disease. The human polyomavirus, JCV, is the etiological agent of the fatal central nervous system (CNS) demyelinating disease, progressive multifocal leukoencephalopathy (PML). PML is the direct result of JCV infection of oligodendrocytes, the myelin producing cell in the CNS. In vivo, JCV can be detected in oligodendrocytes, astrocytes, lymphoid tissue, and peripheral blood of PML patients. In vitro, JCV infects human glial cells, tonsilar stromal cells, and, to a limited extent, human B lymphocytes. The initial step in infection of cells by JCV is at the level of attachment and entry. A specific cell surface receptor for JCV on human glial cells has not been identified. To begin to understand the nature of JCV receptors on human glial cells, large quantities of a previously characterized hybrid JC virus (Mad-1/SVEdelta) were purified. A direct virus binding assay demonstrated that these highly purified and labeled JCV virions bound to a finite number of cellular recepto...Continue Reading
Citations
Apr 1, 2006·Glycoconjugate Journal·Gretchen V GeeWalter J Atwood
Jun 19, 2001·Transplantation Proceedings·J E OhH S Lee
Sep 12, 2001·Advanced Drug Delivery Reviews·L C Norkin
Feb 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Katherine J D A ExcoffonDavid V Schaffer
Jun 17, 2010·The Journal of Infectious Diseases·Moti L Chapagain, Vivek R Nerurkar
Mar 5, 2009·Antimicrobial Agents and Chemotherapy·Margot BrickelmaierLeonid Gorelik
Jul 28, 2010·Journal of Virology·Melissa S MaginnisWalter J Atwood
Feb 9, 2000·Journal of Virology·M T PhoW J Atwood
Oct 3, 2001·Journal of Virology·S Zhang, G Magnusson
Dec 28, 2002·Journal of Virology·Aarthi Ashok, Walter J Atwood
Apr 15, 2003·Journal of Virology·Joanne KimMahmut Safak
Sep 6, 2005·Journal of Virology·Sylvia Eash, Walter J Atwood
Jan 10, 2006·Virology Journal·Moti L ChapagainVivek R Nerurkar
Oct 19, 2010·Cell Host & Microbe·Ursula NeuThilo Stehle
Oct 4, 2013·Journal of Virology·Benedetta AssettaWalter J Atwood
Aug 1, 2014·Journal of Neurovirology·Melissa S MaginnisWalter J Atwood
Nov 21, 2001·The Journal of General Virology·A TouzéP Coursaget
Jun 16, 2009·Virology·Megan L GasparovicWalter J Atwood
Mar 21, 2007·Virology·Armine DarbinyanKamel Khalili
Sep 28, 2002·Virology·Benjamin J Chen, Walter J Atwood
Aug 11, 2011·PLoS Pathogens·Rachel M SchowalterChristopher B Buck
Feb 7, 2009·PLoS Genetics·Shamil R SunyaevLeonid Gorelik
Aug 23, 2012·PLoS Pathogens·Ursula NeuThilo Stehle
Jul 7, 2016·MBio·Benedetta AssettaWalter J Atwood
Jul 22, 2004·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Jennifer TrofeE Steve Woodle
Oct 21, 2020·Viruses·Colleen L Mayberry, Melissa S Maginnis
Jan 5, 2000·Journal of Clinical Microbiology·R S HamiltonE O Major