The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved

Gene
C S SurowyR A Spritz

Abstract

We have isolated cDNA clones encoding the human RD protein, which is closely related to several known nuclear RNA-binding proteins. The RD protein contains a 60-amino acid (aa) tract consisting almost entirely of alternating basic and acidic aa, (RD)n, primarily arginine (Arg; R) and aspartic acid (Asp; D). The protein also contains an 'RNP sequence domain'. Arg-rich tracts and the RNP sequence domain are both features of nuclear RNA-binding proteins. However, we have been unable to detect RNA-binding by the human RD protein. The very strong evolutionary conservation of the mammalian RD protein aa sequence suggests that it plays an important role in the cell.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 15, 1976·Journal of Molecular Biology·J Ross
Mar 1, 1988·Trends in Biochemical Sciences·G DreyfussS Piñol-Roma
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L A RokeachS O Hoch
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas

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Citations

Oct 1, 1994·Protein Science : a Publication of the Protein Society·M Perutz
Mar 1, 1995·Pharmaceutica acta Helvetiae·M F Perutz
May 1, 1993·Current Biology : CB·M F PerutzI De Baere
Aug 12, 2009·Pharmacology, Biochemistry, and Behavior·Richard L BellWilliam J McBride
Jun 1, 1994·Leukemia & Lymphoma·S A Ridge, L M Wiedemann

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