The human skeletal muscle glycogenin gene: cDNA, tissue expression and chromosomal localization

Biochemical and Biophysical Research Communications
F BarbettiG G Consalez

Abstract

Glycogen synthesis is impaired in first degree relatives of subjects with non-insulin-dependent diabetes mellitus and genes relevant to this metabolic pathway are considered reasonable candidates in the pathogenesis of the disease. In skeletal muscle the de novo synthesis of glycogen in primed by an enzyme named glycogenin. We have cloned the glycogenin cDNA from human skeletal muscle mRNA: human glucogenin is a 333 amino acid protein exhibiting 93% identity with rabbit glycogenin. A single transcript of about 2.4 kb, prominent in skeletal muscle, was detected by Northern blot analysis. In situ hybridization unequivocally located the human glycogenin gene to chromosome 3q25.1. Furthermore, we mapped two intronless glycogenin-related sequences to human chromosomes 12 and 13.

Citations

Apr 2, 2010·The New England Journal of Medicine·Ali-Reza MoslemiAnders Oldfors
Apr 7, 2016·BBA Clinical·María M Adeva-AndanyEva Ameneiros-Rodríguez
Dec 27, 2011·Biochimica Et Biophysica Acta·Johanna NilssonAnders Oldfors
Oct 9, 2013·Human Genetics·Eri ImagawaNoriko Miyake
Dec 22, 2017·Neurology. Genetics·Rabah Ben YaouFrançois M Petit
Dec 31, 1997·FEBS Letters·S BaquéJ C Ferrer
Aug 1, 2019·Virchows Archiv : an International Journal of Pathology·Giovanna CenacchiC Angelini
Dec 23, 2020·International Journal of Molecular Sciences·Aitana Almodóvar-PayáTomàs Pinós
Nov 5, 1999·Biochimica Et Biophysica Acta·M van MaanenL J Abraham

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