The human-snail transmission environment shapes long term schistosomiasis control outcomes: Implications for improving the accuracy of predictive modeling

PLoS Neglected Tropical Diseases
David GurarieCharles H King

Abstract

Schistosomiasis is a chronic parasitic trematode disease that affects over 240 million people worldwide. The Schistosoma lifecycle is complex, involving transmission via specific intermediate-host freshwater snails. Predictive mathematical models of Schistosoma transmission have often chosen to simplify or ignore the details of environmental human-snail interaction in their analyses. Schistosome transmission models now aim to provide better precision for policy planning of elimination of transmission. This heightens the importance of including the environmental complexity of vector-pathogen interaction in order to make more accurate projections. We propose a nonlinear snail force of infection (FOI) that takes into account an intermediate larval stage (miracidium) and snail biology. We focused, in particular, on the effects of snail force of infection (FOI) on the impact of mass drug administration (MDA) in human communities. The proposed (modified) model was compared to a conventional model in terms of their predictions. A longitudinal dataset generated in Kenya field studies was used for model calibration and validation. For each sample community, we calibrated modified and conventional model systems, then used them to model o...Continue Reading

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Citations

Oct 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Chelsea L WoodGiulio A De Leo
Jan 1, 2020·The American Journal of Tropical Medicine and Hygiene·Joseph W WalkerDaniel G Colley
Feb 29, 2020·Scientific Reports·Jeremias M BeckerMatthias Liess
Feb 1, 2019·Tropical Medicine and Infectious Disease·Stefanie J KrauthPoppy H L Lamberton
Jun 27, 2019·International Journal of Environmental Research and Public Health·Yingnan NiuYing Cui
Nov 25, 2019·Developmental and Comparative Immunology·Maria G CastilloCesar E Montelongo
Dec 15, 2020·Nature Sustainability·Christopher M HooverGiulio A De Leo

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Methods Mentioned

BETA
MDA
MDAs

Software Mentioned

MDA

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