The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter

Genomics
S V KozlovP Sonderegger

Abstract

The human TAX-1 gene (HGMW-approved symbol TAX1) is located on chromosome 1 (1q32.1) and encodes the neuronal cell adhesion molecule TAG-1/axonin-1. The gene product, termed TAG-1 in the rat and axonin-1 in the chicken, is composed of six immunoglobulin (Ig)-like and four fibronectin type III (FNIII)-like domains. It is found predominantly on the axons of particular nerve fiber tracts during neural development, and it has been demonstrated to function as a potent substratum for neurite outgrowth in vitro. Here we report the cloning and structural characterization of the TAX-1 gene. The transcribed region of the TAX-1 gene extends over about 40 kb. Like its chicken homologue, the human TAX-1 gene consists of 23 exons. Two GT/CA microsatellites were localized in the first intron; a polymorphism was found for one of them. Reporter gene analysis with serially truncated fragments of the 5'-flanking region indicated that a 164-bp fragment located immediately upstream of the putative transcription initiation site was sufficient to function as a basal promoter.

Citations

May 7, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tobias DerfussEdgar Meinl
Nov 13, 2001·The European Journal of Neuroscience·M Alvarez-DoladoA Muñoz
Jan 1, 1997·Annual Review of Cell and Developmental Biology·F S Walsh, P Doherty
Nov 23, 2016·Molecular and Cellular Neurosciences·Gianfranco GennariniAndrew J W Furley
Mar 31, 2017·PloS One·Samadrita BhattacharyyaNikhil Vilas Munshi
Nov 14, 1997·The Journal of Biological Chemistry·B HasselH Volkmer
Dec 23, 1998·European Journal of Immunology·I ChrétienL Du Pasquier
Oct 12, 2012·Neurochemical Research·Hansjürgen VolkmerFritz G Rathjen
Dec 12, 2018·Neural Regeneration Research·Madhurima ChatterjeeCharlotte E Teunissen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.