Oct 1, 1985

The human Thy-1 gene: structure and chromosomal location

Proceedings of the National Academy of Sciences of the United States of America
T SekiJ Silver

Abstract

The human Thy-1 gene has been isolated and sequenced and compared to the rat and mouse Thy-1 genes. All three genes are organized in the same way: one exon encoding the majority of the signal peptide, another encoding the transmembrane segment, and a third encoding the remainder of the protein. One major structural difference between the human and rodent Thy-1 glycoproteins is that the former contains two instead of three glycosylation sites. RNA blot analysis of a human T-cell line expressing the T3 complex showed an absence of Thy-1 mRNA, excluding the possibility that Thy-1 represents one of the component chains of T3. The structural gene for human Thy-1 was localized to the long arm of chromosome 11 by nucleic acid hybridization to genomic DNA isolated from somatic cell hybrids.

Mentioned in this Paper

Northern Blotting
Exons
Nucleic Acid Hybridization Procedure
Glycoproteins
Proteins, Recombinant DNA
THY1
Integral to Membrane
Genome Mapping
B-Lymphocytes
Protein Glycosylation

About this Paper

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