PMID: 2982724Jan 1, 1985Paper

The human thyroglobulin gene: a polymorphic marker localized distal to C-MYC on chromosome 8 band q24

Human Genetics
F BaasG J van Ommen


The human thyroglobulin (Tg) gene is localized to chromosome 8 and regionally to band q24 as shown independently by both in situ hybridization techniques and Southern blot analysis of human-rodent somatic cell hybrids. Analysis of hybrids derived from a Burkitt lymphoma, with a translocation breakpoint in the oncogene c-myc, shows that the Tg gene is located distal from c-myc, towards the telomere of the long arm of chromosome 8. The finding of two high frequency restriction fragment length polymorphisms (RFLPs) in the 5' part of the Tg gene results in heterozygosity for at least one marker at chromosome 8, band q24, in 50% of a Caucasian population. These RFLPs cannot only be used for the study of inborn errors in Tg synthesis but also for linkage studies in the telomeric region of chromosome 8q.


Aug 2, 1979·The New England Journal of Medicine·A J Van HerleJ E Dumont
Apr 25, 1983·Nucleic Acids Research·G J van OmmenJ J de Vijlder
Apr 25, 1984·Nucleic Acids Research·V E AvvedimentoR Di Lauro
Jan 1, 1982·Human Genetics·J M ScheresT W Hustinx


Jul 1, 1992·Somatic Cell and Molecular Genetics·G P KaurR S Athwal
Mar 1, 1994·Somatic Cell and Molecular Genetics·J E ParrishD E Wells
Jan 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·T E Daskalchuk, S M Schmutz
Feb 25, 2000·Cancer Genetics and Cytogenetics·P E CrossenM J Morrison
Jul 11, 2001·Endocrinology and Metabolism Clinics of North America·J I Torréns, H B Burch
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B A Taylor, L Rowe
Jan 1, 1991·Thyroid : Official Journal of the American Thyroid Association·H M TargovnikG Medeiros-Neto
Sep 29, 2005·Thyroid : Official Journal of the American Thyroid Association·Jussara Vono-TonioloPeter Kopp
Jul 11, 1986·Nucleic Acids Research·F BaasJ J de Vijlder
Jan 12, 1987·Nucleic Acids Research·P SimonG Vassart
May 7, 2002·Journal of Pediatric Hematology/oncology·Erna M C MichielsMario A J A Hermsen
Sep 1, 1987·Journal of Medical Genetics·S R DiehlA D Roses
Nov 1, 1988·Journal of Medical Genetics·S Wood
Jul 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Carina M Rivolta, H M Targovnik
Jan 23, 2010·Molecular and Cellular Endocrinology·H M TargovnikCarina M Rivolta
Dec 22, 2004·Arquivos brasileiros de endocrinologia e metabologia·Jussara Vono-Toniolo, Peter Kopp
Nov 15, 2018·Anais Da Academia Brasileira De Ciências·Érika BrancoAna Rita DE Lima
Aug 15, 1989·International Journal of Cancer. Journal International Du Cancer·S AdolphG W Bornkamm
Feb 1, 1993·International Journal of Cancer. Journal International Du Cancer·K HuppiJ F Mushinski
Aug 29, 2006·Arquivos brasileiros de endocrinologia e metabologia·Sabrina Mendes CoelhoDenise Pires de Carvalho
Feb 1, 1989·Biochimie·Y MalthiéryS Lissitzky

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