The human toxome project

ALTEX
Mounir BouhifdThomas Hartung

Abstract

The Human Toxome Project, funded as an NIH Transformative Research grant 2011-2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectroscopy-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies.

Citations

Sep 28, 2015·Regulatory Toxicology and Pharmacology : RTP·Daniel W Nebert, Magnus Ingelman-Sundberg
Sep 12, 2015·Chemical Research in Toxicology·Ricard Garcia-SernaJordi Mestres
Mar 28, 2016·Archives of Toxicology·Mardas DaneshianBob van de Water
Jul 9, 2016·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·James GigrichThomas Holzer
Aug 7, 2016·Frontiers in Pharmacology·George D Loizou
Oct 11, 2016·Expert Opinion on Drug Metabolism & Toxicology·Thomas Hartung
Apr 1, 2017·Chemical Research in Toxicology·Thomas HartungShana J Sturla
Oct 21, 2017·Archives of Toxicology·Marcel LeistJan G Hengstler
Nov 3, 2016·Alternatives to Laboratory Animals : ATLA·Jenny McCann, Terry McCann
May 28, 2021·Current Protocols·Amin SobhChristopher D Vulpe
May 22, 2018·Environmental Science & Technology·Kun Zhang, Yanbin Zhao

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Methods Mentioned

BETA
gene array

Software Mentioned

iCSS Dashboard
OpenLAB ELN
Toxicity Forecaster
PoT
TT21c
GeneSpring
toxome
ExpoCast

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