The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein.

The Journal of Biological Chemistry
E CrozeH D Perez

Abstract

We used specific antibodies recognizing the receptor 1 (IFNAR1) and the recently cloned receptor 2.2 (IFNAR2.2) chains of the human type I interferon receptor complex to demonstrate that the interferon beta (IFN-beta)-specific receptor-associated phosphoprotein is IFNAR2.2 and not an unknown or additional receptor component. Immunoprecipitation experiments demonstrated that IFNAR2.2 is present in Daudi cells as a cell surface protein of approximately 90-100 kDa, which is tyrosine-phosphorylated and associated with IFNAR1, upon stimulation of cells with IFN-beta. IFNAR2.2 was not detected associated with IFNAR1 in cells stimulated with IFN-alpha, suggesting differences in receptor interaction between the two type I interferons. Both IFNAR1 and IFNAR2.2 undergo tyrosine phosphorylation upon induction by either IFN-alpha or IFN-beta. Therefore, it is unclear as to why IFNAR2.2 is not detectable in IFNAR1 immunoprecipitates in IFN-beta-treated cells. These data suggest that, although IFN-alpha and IFN-beta may utilize similar receptor chains, they interact with IFNAR1 and IFNAR2.2 in different ways.

References

Jan 1, 1987·Annual Review of Biochemistry·S PestkaC E Samuel
May 1, 1985·The Journal of General Virology·G MerlinM Aguet
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·S N ConstantinescuL M Pfeffer
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·S N ConstantinescuL M Pfeffer
Jan 1, 1995·Annual Review of Biochemistry·C Schindler, J E Darnell
Nov 3, 1995·The Journal of Biological Chemistry·D Russell-HardeE Croze
Aug 1, 1995·Molecular and Cellular Biology·B CohenM Rubinstein
Jan 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G UzéK E Mogensen
Jan 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D Russell-HardeE Croze
Feb 1, 1995·Trends in Genetics : TIG·J N Ihle, I M Kerr
May 1, 1995·Journal of Leukocyte Biology·D NovickM Rubinstein
Jan 1, 1996·Molecular and Cellular Biology·S A QureshiJ E Darnell
Jun 1, 1996·Molecular and Cellular Biology·E A BachR D Schreiber
Jul 1, 1996·Immunology Today·B A Fields, R A Mariuzza

❮ Previous
Next ❯

Citations

Jun 11, 2005·Journal of Molecular Biology·Peter LamkenJacob Piehler
May 3, 2003·Pharmacology & Therapeutics·Leonidas C Platanias
Nov 24, 1999·Experimental Hematology·L C Platanias, E N Fish
Aug 21, 2013·Nature Immunology·Surinder Kaur, Leonidas C Platanias
Nov 30, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D NovickA R Arulanandam
Mar 26, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Antonio J da SilvaPaula S Hochman
Oct 25, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Melissa M Brierley, Eleanor N Fish
Nov 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K E MogensenG Uzé
Aug 24, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·I M GrumbachL C Platanias
Dec 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M R Sandhya Rani, Richard M Ransohoff
Sep 26, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M R Sandhya RaniRichard M Ransohoff
Mar 3, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Joris ErdmannCasper H J van Eijck
Oct 6, 1998·Annual Review of Biochemistry·G R StarkR D Schreiber
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·C H YangL M Pfeffer
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·M KarpusasS Goelz
Jan 29, 2011·International Journal of Cell Biology·Tiffany TranEd Croze
Feb 5, 2005·Cancer Immunology, Immunotherapy : CII·Pierosandro TagliaferriSalvatore Venuta
Jun 27, 1998·Leukemia & Lymphoma·R G Hawley, L C Berger
Jun 21, 2005·Journal of Cellular and Molecular Medicine·Kenji Oritani, Yuzuru Kanakura
Jun 27, 2012·The Biochemical Journal·Véronique Francois-NewtonSandra Pellegrini
Jul 1, 2010·International Journal of Radiation Biology·Eva JöstHeinz Schmidberger
Sep 19, 2006·Immunity·Anette H H van Boxel-DezaireGeorge R Stark
Sep 17, 1998·Journal of Molecular Biology·M LewerenzG Uzé
Feb 26, 2008·Journal of Molecular Biology·Jennifer Julia StrunkJacob Piehler
Sep 27, 2006·Protein Science : a Publication of the Protein Society·Sabine R Quadt-AkabayovJacob Anglister
Aug 17, 2006·The Journal of Clinical Endocrinology and Metabolism·Peter M van KoetsveldLeo J Hofland
Jun 18, 2009·Physiological Genomics·D J PappasS E Baranzini
Jan 12, 2002·The Journal of Biological Chemistry·Vinh-Phúc NguyenJohn J Krolewski
Jan 16, 1999·The Journal of Biological Chemistry·M R RaniR M Ransohoff
May 9, 1998·The Journal of Biological Chemistry·L RunkelK Mogensen
Jun 9, 2004·International Journal of Cancer. Journal International Du Cancer·T Charis WagnerEd Croze
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E CrozeO Colamonici
Jan 15, 2009·American Journal of Physiology. Endocrinology and Metabolism·Giovanni VitaleLeo J Hofland
Aug 27, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria SjöstrandMarie Wahren-Herlenius
Dec 19, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R J MintzerA Johns

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.