PMID: 2870017Mar 1, 1986Paper

The human tyrosine aminotransferase gene mapped to the long arm of chromosome 16 (region 16q22----q24) by somatic cell hybrid analysis and in situ hybridization

Human Genetics
D E BartonU Francke

Abstract

Tyrosine aminotransferase (TAT; EC 2.6.1.5) is a liver enzyme involved in amino acid metabolism and gluconeogenesis. Low levels of TAT have been implicated in several inherited disorders, particularly tyrosinemia II (Richner-Hanhart syndrome). We have determined the chromosomal location of the human TAT gene by Southern blot hybridization analysis of DNAs from 18 human X rodent hybrid cell lines, using a rat cDNA probe. The results indicate that the TAT gene maps to chromosome 16. Analysis of two hybrids containing a rearranged chromosome 16 allowed assignment of the TAT locus to 16q22----24. In situ hybridization to human metaphase chromosomes confirmed this regional assignment.

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Citations

Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S AlonsoM Buckingham
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J D Ceci
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Sep 1, 1987·Genomics·A G SearleV J Buckle
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M ManginD E Barton
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J J DavidsonM W Kilimann
Oct 9, 1995·American Journal of Medical Genetics·M H el-BadramanyT I Farag
Mar 1, 1995·Ophthalmic Genetics·A I al-Hemidan, S A al-Hazzaa
Nov 8, 2005·Annals of Saudi Medicine·Jihad T Al-RatroutNaseem A Ansari

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