The Human Vaccines Project: Towards a comprehensive understanding of the human immune response to immunization

Human Vaccines & Immunotherapeutics
Stacey L Wooden, Wayne C Koff

Abstract

Although the success of vaccination to date has been unprecedented, our inadequate understanding of the details of the human immune response to immunization has resulted in several recent vaccine failures and significant delays in the development of high-need vaccines for global infectious diseases and cancer. Because of the need to better understand the immense complexity of the human immune system, the Human Vaccines Project was launched in 2015 with the mission to decode the human immune response to accelerate development of vaccines and immunotherapies for major diseases. The Project currently has three programs: 1) The Human Immunome Program, with the goal of deciphering the complete repertoire of B and T cell receptors across the human population, termed the Human Immunome, 2) The Rules of Immunogenicity Program, with the goal of understanding the key principles of how a vaccine elicits a protective and durable response using a system immunology approach, and 3) The Universal Influenza Vaccine Initiative (UIVI), with the goal of conducting experimental clinical trials to understand the influence of influenza pre-exposures on subsequent influenza immunization and the mechanisms of protection. Given the dramatic advances in...Continue Reading

References

Oct 28, 2010·Current Opinion in HIV and AIDS·Guy de Bruyn
Oct 4, 2011·Nature Reviews. Microbiology·Stanley A Plotkin, Susan L Plotkin
Apr 11, 2013·Human Vaccines & Immunotherapeutics·Carina RosenbergEskild Petersen
Apr 16, 2013·Human Vaccines & Immunotherapeutics·Janet M Lord
Oct 12, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christel HoestUNKNOWN MAL-ED Network Investigators
Jan 13, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sabra L KleinEleanor N Fish
Feb 28, 2015·Aging Cell·Carmen Giefing-KröllBeatrix Grubeck-Loebenstein
May 13, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Beate Kampmann, Christine E Jones
Sep 15, 2015·Cambridge Quarterly of Healthcare Ethics : CQ : the International Journal of Healthcare Ethics Committees·Aysha Akhtar
Oct 21, 2015·Expert Review of Vaccines·James E Crowe, Wayne C Koff
Feb 3, 2016·Human Vaccines & Immunotherapeutics·Ursula WiedermannAngelika Wagner
Feb 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Adolfo García-Sastre
Apr 15, 2016·Methods in Molecular Biology·Johannes Sollner
Jun 22, 2016·Scientific Reports·Shigui YangLanjuan Li

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Citations

Oct 15, 2018·Immunology·René H M RaevenGideon F A Kersten
Oct 10, 2018·Expert Review of Vaccines·Natalie A ProwAndreas Suhrbier
Mar 16, 2019·Nature Communications·Andrew CaplinGeorge Thurston
Oct 15, 2019·Immunological Reviews·Claire LoiseauDenise L Doolan
Jul 15, 2020·Expert Opinion on Drug Discovery·Giulia RussoFrancesco Pappalardo
Oct 5, 2019·Scientific Reports·Nancy ChaayaSéverine Padiolleau-Lefèvre
Jul 17, 2020·Frontiers in Immunology·Richard B KennedyGregory A Poland
Oct 30, 2019·Annals of the New York Academy of Sciences·Jennifer CableRino Rappuoli

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

JCVI
DIABLO
NetAnalyst

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