PMID: 11311832Apr 20, 2001Paper

The human Y chromosome: function, evolution and disease

Forensic Science International : Synergy
L Quintana-MurciK McElreavey

Abstract

The human Y chromosome is strictly paternally inherited and, in most of its length, does not recombine during male meiosis. These features make the Y a very useful genetic marker for different purposes. In the last decade, the Y has been increasingly used to investigate the evolution, migrations and range expansions of modern humans. The possibility to construct highly informative Y chromosome haplotypes has also had a significant impact in forensic studies and paternity testing. All these studies assume that the Y chromosome markers used are selectively neutral. However, recent experimental and statistical analyses suggest that both positive and negative selection are acting on the Y chromosome and, consequently, may influence Y chromosome haplotype distribution in the general population. Current data suggest that the effects of selection on patterns of Y chromosome distribution are minimal, however as interest focuses on biological functions of the Y chromosome which have a major impact on male fitness such as fertility, these assumptions may be challenged. This review briefly describes the genes and biological functions of the human Y chromosome and its use in disentangling the origin and history of human populations. An ove...Continue Reading

References

Feb 1, 1991·Genomics·Y NakahoriY Nakagome
Jul 1, 1989·Behavior Genetics·J H van AbeelenW A Lemmens
Jan 1, 1987·Nature·R L CannA C Wilson
Sep 11, 1987·Science·R Lewin
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L L Cavalli-SforzaJ Mountain
Nov 11, 1987·Nucleic Acids Research·J ArnemannJ Schmidtke
Dec 14, 1985·British Medical Journal·M G HullK M Desai
Feb 1, 1974·Genetical Research·J M Smith, J Haigh
Nov 23, 1995·Nature·M F Hammer
Nov 1, 1993·Genes, Chromosomes & Cancer·S HunterV Varma
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·S HoraiN Takahata
Sep 1, 1995·Nature Genetics·S D PenaT Oyunsuren
Jul 15, 1995·Cancer Genetics and Cytogenetics·G SauterF M Waldman
Feb 2, 1995·The New England Journal of Medicine·J AugerP Jouannet
Feb 1, 1994·Nature Genetics·P GillK Sullivan
Oct 1, 1993·Human Genetics·G A Rappold
Aug 1, 1993·Genetics·B CharlesworthD Charlesworth
Sep 30, 1993·International Journal of Cancer. Journal International Du Cancer·R CenterO M Garson
Oct 1, 1995·Physics in Medicine and Biology·T Baba-Hamed, R D Speller
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·P A UnderhillL L Cavalli-Sforza
Nov 1, 1995·Trends in Genetics : TIG·M A Jobling, C Tyler-Smith
Jun 1, 1996·Nature Genetics·J A ArmourA J Jeffreys
Feb 1, 1996·Current Biology : CB·B Charlesworth
Sep 1, 1996·The Quarterly Review of Biology·L D HurstB O Bengtsson
Jan 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J W EllisonL J Shapiro
Jan 1, 1997·International Journal of Legal Medicine·M A JoblingC Tyler-Smith
Jan 1, 1997·International Journal of Legal Medicine·M KayserL Roewer
Jan 1, 1997·International Journal of Legal Medicine·P de KnijffL Roewer

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Citations

Feb 1, 2011·Forensic Science, Medicine, and Pathology·Branka GrškovićSimun Anđelinović
Dec 10, 2013·Forensic Science International. Genetics·Wenjing ChenHongyu Sun
Apr 26, 2003·Trends in Endocrinology and Metabolism : TEM·Fadi J CharcharAnna F Dominiczak
Nov 1, 2007·PloS One·Pim van HooftArmanda D S Bastos
May 6, 2014·Frontiers in Neuroendocrinology·S T NgoP A McCombe
Aug 22, 2015·American Journal of Human Biology : the Official Journal of the Human Biology Council·Soumaya Triki-FendriAhmed Rebai
Aug 19, 2015·Journal of Proteome Research·Deivendran RengarajMyung-Geol Pang
Sep 13, 2018·Journal of Assisted Reproduction and Genetics·Stacy Colaco, Denny Sakkas
Sep 23, 2010·Molecular Biology Reports·Branka GrškovićSimun Anđelinović
May 13, 2020·Journal of Assisted Reproduction and Genetics·C S FranchimE C Baracat
Aug 30, 2003·Analytical Chemistry·T A BrettellR Saferstein

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