The humanistic and economic burden of treatment-resistant depression in Europe: a cross-sectional study

BMC Psychiatry
Dena H JaffeTom R Denee

Abstract

A patient is considered to suffer from treatment resistant depression (TRD) when consecutive treatment with two products of different pharmacological classes, used for a sufficient length of time at an adequate dose, fail to induce a clinically meaningful effect (inadequate response). The primary aim of the current study was to examine the humanistic and economic burden of TRD in five European countries, France, Germany, Italy, Spain and the United Kingdom, by comparing with non-treatment resistant depression (nTRD) and general population respondents. The sample for this retrospective observational study was taken from the 2017 National Health and Wellness Survey conducted in five European countries. Demographic and patient characteristics were examined for TRD patients compared to respondents with nTRD and to the general population using chi-square tests or one-way analysis of variance for categorical or continuous variables, respectively. Generalized linear models were performed to examine group differences after adjusting these estimates for confounders. A total 52,060 survey respondents were examined, of which 2686 and 622 were considered to have non-treatment resistant and treatment-resistant depression, respectively. Rela...Continue Reading

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Citations

Nov 4, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Siegfried KasperAllan H Young
Jan 27, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katharine DunlopConor Liston
Jul 10, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Matteo RuggeriFabrizio Starace
Aug 31, 2021·Nordic Journal of Psychiatry·Stine Bjerrum MoellerPoul Videbech
Dec 2, 2021·International Journal of Psychiatry in Clinical Practice·Philip BrennerJohan Reutfors

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