The hunt for the secrets of uveal melanoma

Clinical & Experimental Ophthalmology
Carol L Shields

Abstract

The many secrets of uveal melanoma are being uncovered. Information on host and environmental factors that predispose to uveal melanoma has been published. The most important factors include light eye colour, fair skin, inability to tan and chronic sun exposure. Clinical clues that are visible on ophthalmoscopy have been shown to be significant factors in predicting growth of small borderline tumours and allow for early detection of melanoma. These factors include thickness over 2 mm, subretinal fluid, symptoms, orange pigment overlying the tumour and tumour margin within 3 mm of the disc. Refined methods of cytogenetic analysis have identified several chromosomal mutations associated with uveal melanoma. Currently, the most important mutation proves to be chromosome 3 monosomy, an abnormality associated with greater risk for metastatic disease.

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Citations

Sep 16, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Virginie HouleGuy S Allaire
Jul 16, 2010·Dermatology Research and Practice·Thomas van den BoschAnnelies de Klein
Jan 23, 2010·Clinical & Experimental Ophthalmology·Victoria A Cartwright, Peter J Savino
Apr 12, 2014·Melanoma Research·Marius L HaiducuSunil Kalia
Apr 9, 2009·Journal of Experimental & Clinical Cancer Research : CR·Sebastian Di CesareMiguel N Burnier
Apr 17, 2008·Clinical & Experimental Ophthalmology·Peter William Hadden
May 14, 2009·Seminars in Ophthalmology·Pooja BhatRobert Folberg
Jun 26, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gary G Schwartz

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