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The HVCN1 channel conducts protons into the phagocytic vacuole of neutrophils to produce a physiologically alkaline pH

bioRxiv

Mar 27, 2014

Adam P LevineAnthony W Segal

Abstract

Activation of the NADPH oxidase (NOX2) of the phagocytic vacuole of neutrophils is essential for innate immunity. Sustained activity of the oxidase requires that charge movements across the membrane are balanced. A role for the proton channel, HVCN1, has been proposed but not proven. Us...read more

Mentioned in this Paper

Base
CYBB
Normal Cell
Body Fluid Compartments
Extracellular
Enzymes, antithrombotic
Membrane
HVCN1 gene
Valinomycin
Oxidase
1
9
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The HVCN1 channel conducts protons into the phagocytic vacuole of neutrophils to produce a physiologically alkaline pH

bioRxiv

Mar 27, 2014

Adam P LevineAnthony W Segal

PMID: 990003616

DOI: 10.1101/003616

Abstract

Activation of the NADPH oxidase (NOX2) of the phagocytic vacuole of neutrophils is essential for innate immunity. Sustained activity of the oxidase requires that charge movements across the membrane are balanced. A role for the proton channel, HVCN1, has been proposed but not proven. Us...read more

Mentioned in this Paper

Base
CYBB
Normal Cell
Body Fluid Compartments
Extracellular
Enzymes, antithrombotic
Membrane
HVCN1 gene
Valinomycin
Oxidase
1
9

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