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The HVCN1 channel conducts protons into the phagocytic vacuole of neutrophils to produce a physiologically alkaline pH

bioRxiv

Mar 27, 2014

Adam P. LevineAnthony W. Segal

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Abstract

Activation of the NADPH oxidase (NOX2) of the phagocytic vacuole of neutrophils is essential for innate immunity. Sustained activity of the oxidase requires that charge movements across the membrane are balanced. A role for the proton channel, HVCN1, has been proposed but not proven. Us...read more

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Enzymes, antithrombotic
Enzymes, peripheral vasodilators
Cytoplasmic
Phagocytes
Absolute Neutrophil Count
Human Cell Line
Body Fluid Compartments
Microscopy, Confocal
Cytoplasmic Matrix
Enzymes, hematological
1
9
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  • The HVCN1 channel conducts protons into the phagocytic vacuole of neutrophils to produce a physiologically alkaline pH

    bioRxiv

    Mar 27, 2014

    Adam P. LevineAnthony W. Segal

    PMID: 990003616

    DOI: 10.1101/003616

    Abstract

    Activation of the NADPH oxidase (NOX2) of the phagocytic vacuole of neutrophils is essential for innate immunity. Sustained activity of the oxidase requires that charge movements across the membrane are balanced. A role for the proton channel, HVCN1, has been proposed but not proven. Us...read more

    Mentioned in this Paper

    Enzymes, antithrombotic
    Enzymes, peripheral vasodilators
    Cytoplasmic
    Phagocytes
    Absolute Neutrophil Count
    1
    9

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