Abstract
Diazinon (DZN) is an organophosphate insecticide that affects the liver adversely. Ginger exhibits antioxidant properties. We investigated the hepatoprotective effects of an ethanolic extract of ginger root on DZN induced hepatotoxicity. We measured total phenolics and flavonoids in the hydroalcoholic extract. We used Wistar rats divided into four groups: control, 100 mg/kg/day ginger by gavage, 10 mg/kg/day DZN intraperitoneally, and ginger + DZN group treated with ginger 1 h before DZN. All treatments were for 30 consecutive days. One day after the last treatment, we evaluated oxidative stress parameters, serum biochemistry, histopathology and immunohistochemistry. The ginger extract contained 101.33 ± 2.73 mg total flavonoid and 237.9 ± 3 mg total phenolic content/g dry ginger plant roots. We found that DZN increased oxidative stress significantly. Histopathology of the liver tissue was consistent with increased AST, ALT, and ALP. Ginger extract treatment reduced oxidative stress and improved histopathology. DZN increased caspase-3 immunoreactivity and ginger extract reduced it. Ginger extract exhibited hepatoprotective effects against DZN induced hepatic injury owing to its antioxidant and anti-apoptotic activity.
References
Jun 1, 2005·Toxicology·Suna KalenderYusuf Kalender
Feb 23, 2008·Toxicology·Josef OzerShelli Schomaker
Apr 18, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A S El-SharakyS M Eweda
Oct 16, 2009·Der Urologe. Ausg. A·A JanitzkyU-B Liehr
Jan 26, 2010·Neuroscience·T RushD Lobner
Oct 12, 2010·The Journal of Toxicological Sciences·Nagaraja HaleagraharaAnupama Kulur
Nov 18, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Evan Prince SabinaMahaboobkhan Rasool
Feb 15, 2013·Toxicology and Industrial Health·Parisa LariHossein Hosseinzadeh
Aug 10, 2013·Journal of Dietary Supplements·Amal S Abdel-AzeemEman M El-Sayed
Nov 6, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Fatma M El-Demerdash, Hoda M Nasr
May 30, 2015·Iranian Red Crescent Medical Journal·Halil BeydilliHamdi Sozen
Oct 23, 2015·Environmental Science and Pollution Research International·Manel BoussabbehHassen Bacha
May 6, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vipin A VVenkateswaran G
Jul 3, 2017·Reproductive Toxicology·Ramezan Ali NaeimiSeyed Jalal Hosseinimehr
Aug 7, 2018·International Journal of Preventive Medicine·Mona MohammadianFereshteh Talebpour Amiri
Oct 3, 2018·Research in Pharmaceutical Sciences·Maedeh HamzehFereshteh Talebpour Amiri
Mar 21, 2020·Iranian Journal of Biotechnology·Gautam Krishnan, Utpal Roy