The Hydrocarbon Staple & Beyond: Recent Advances Towards Stapled Peptide Therapeutics that Target Protein-Protein Interactions

Current Topics in Medicinal Chemistry
Robert A HillmanMichael A Bertucci

Abstract

Anomalous protein-protein interactions (PPIs) have been correlated to a variety of disease states, such as cancer, infectious disease, neurological disorders, diabetes, endocrine disorders and cardiovascular disease. Stapled peptides are an emerging intervention for these PPIs due to their improved structural rigidity and pharmacokinetic properties relative to unstapled peptides. This review details the most recent advances in the field of stapled peptide therapeutics, including the increasing variety of PPIs being targeted and types of peptide staples being employed.

Citations

Oct 12, 2018·Medicinal Research Reviews·Kornelia J SkowronTerry W Moore
Oct 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo Wu, Weiping Zheng
Jun 12, 2021·The Journal of Physical Chemistry. B·Luana Janaína de CamposMartin Conda-Sheridan
May 16, 2019·Chemical Reviews·Patrick G DoughertyDehua Pei

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